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Amprenavir is an antiretroviral protease inhibitor used in the therapy and prevention of human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS).


Amylocaine was the first synthetic local anesthetic. It was formerly used mostly in spinal anesthesia.

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Anagliptin is a pharmaceutical drug for the treatment of type 2 diabetes mellitus. Anagliptin belongs to the class of anti-diabetic drugs known as dipeptidyl peptidase-4 inhibitors or "gliptins".

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Anagrelide is a drug used for the treatment of essential thrombocytosis, or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia.

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Aniracetam is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid soluble and has possible cognition enhancing effects.

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Antipyrine is an analgesic and antipyretic. It was first synthesized by Ludwig Knorr in 1883. It is formed by reducing diortho- dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 °C.

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Apaziquone is an indolequinone that is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptotic cell death. This activity is preferentially expressed in neoplastic cells. It has been applied in clinical studies for the treatment of superficial bladder cancer.

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Apremilast is a novel, orally available PDE4 inhibitor that inhibits spontaneous TNFα production from human rheumatoid synovial membrane cultures, ex-vivo, with similar efficacy to rolipram.

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Arfendazam is a drug which is a benzodiazepine derivative. It is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABAA receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses. It produces an active metabolite lofendazam, which is thought to be responsible for part of its effects.

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