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Clofibrate

Clofibrate is a fibrate. It is a lipid lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It is proved that it can increase the level of HDL as well. It can induce SIADH, syndrome of inappropriate secretion of antidiuretic hormone ADH (vasopressin).

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Clominorex

Clominorex is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was developed as an appetite suppressant.

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Clomiphene

Clomifene is a selective estrogen receptor modulator that increases production of gonadotropins by inhibiting negative feedback on the hypothalamus. It is used mainly for ovarian stimulation in female infertility due to anovulation.

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Clonazepam

Clonazepam is a benzodiazepine derivative having anticonvulsant, muscle relaxant, and very potent anxiolytic properties. It is a chlorinated derivative of nitrazepam and therefore a nitrobenzodiazepine. Benzodiazepines such as clonazepam have a fast onset of action and high effectiveness rate and low toxicity in overdose but have drawbacks due to adverse reactions including paradoxical effects, drowsiness, and cognitive impairment. Cognitive impairments can persist for at least 6 months after withdrawal of clonazepam; it is unclear whether full recovery of memory functions occurs.

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Cloprednol

Cloprednol is a glucocorticoid. It is synthetic. It has been investigated for use in asthma.

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Clorgyline

Clorgyline is an irreversible and selective inhibitor of monoamine oxidase A that is used in scientific research. It is structurally related to pargyline.

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Cloxazolam

Cloxazolam is a drug which is a benzodiazepine derivative. It is metabolised into the active metabolite chlordesmethyldiazepam. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.

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Cobicistat

Cobicistat is a licensed drug for use in the treatment of infection with the human immunodeficiency virus (HIV).cobicistat is of interest not for its anti-HIV properties, but rather its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor currently under investigation itself. Cobicistat is a component of the four-drug, fixed-dose combination HIV treatment elvitegravir/cobicistat/emtricitabine/tenofovir.Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.

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Codorphone

Codorphone is an opioid analgesic drug. It is an analogue of hydrocodone substituted with an 8-ethyl group and an N-cyclopropylmethyl group. It is a mixed agonist-antagonist at the μ-opioid receptor, and is slightly more potent than codeine in analgesic effects but associated with somewhat greater side effects.

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Colchicine

Colchicine is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum. It was used originally to treat rheumatic complaints, especially gout, and still finds use for these purposes today despite dosing issues concerning its toxicity. It was also prescribed for its cathartic and emetic effects. Its present medicinal use is in the treatment of gout and familial Mediterranean fever; it can also be used as initial treatment for pericarditis and preventing recurrences of the condition. It is a common medication used in the treatment of Behcet's disease. It is also being investigated for its use as an anti-cancer drug. In neurons, axoplasmic transport is disrupted by colchicine.

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