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Golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity.Golvatinib is currently under evaluation in a phase I clinical trial, it may overcome HGF-induced resistance to gefitinib and next-generation EGFR-TKIs.
Guanfacine is an agonist of the α2A subtype of norepinephrine receptors. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention abilities via modulating post-synaptic α2A receptors in the prefrontal cortex. It lowers both systolic and diastolic blood pressure by activating the central nervous system α-2a norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone.
Haloprogin is an antifungal drug used to treat athlete's foot and other fungal infections.
Hesperetin belongs to the flavanone class of flavonoids.Hesperetin in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.It is a cholesterol lowering flavanoid found in a number of citrus juices.It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%.It may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic,vasoprotective and anticarcinogenic actions.
Hesperidin is a flavanone glycoside found abundantly in citrus fruits. Its name is derived from the Hesperides nymphs of Greek mythology. It is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. In human nutrition, it contributes to the integrity of the blood vessels. Various preliminary studies reveal novel pharmaceutical properties. It reduces cholesterol and blood pressure in rats. It has anti-inflammatory effects. It is also a potential sedative, possibly acting through opioid or adenosine receptors. Hesperidin also showed the ability to penetrate the blood-brain barrier in an in vitro model.
Hexylcaine is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.
Ichthammol is a product of natural origin obtained in the first step by dry distillation of sulfur-rich oil shale. It is used in medicine as a remedy for treating some skin diseases, such as acne, eczema and psoriasis. It is commonly used in 10% or 20% concentrate ointment form as a drawing salve. However, it does not actually draw out foreign objects. It does soften skin over a boil or spot allowing it to come to a head sooner. It also decreases microorganisms in the area surrounding a skin condition.
Idarubicin is an anthracycline antileukemic drug. It inserts itself into DNA and prevents DNA from unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake. It belongs to the family of drugs called antitumor antibiotics. It is currently combined with cytosine arabinoside as a first line treatment of acute myeloid leukemia.
Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer and also for the treatment of various soft tissue sarcomas.
Ilepcimide is a piperidine anticonvulsant used in China.
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