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Lofendazam is an organic molecule which is a benzodiazepine derivative. It is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam. Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.


Lofexidine is an alpha2-adrenergic receptor agonist, historically used as a short-acting anti-hypertensive, but more commonly used to alleviate physical symptoms of heroin and opiate withdrawal.

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Lonafarnib is a farnesyl-OH-transferase inhibitor that is being investigated in a human clinical trial as a potential treatment for progeria.

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Loperamide, a synthetic piperidine derivative, is an opioid drug effective against diarrhea resulting from gastroenteritis or inflammatory bowel disease. It was developed at Janssen Pharmaceutica.

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Loprazolam is a drug which is an imidazole benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is licensed and marketed for the short term treatment of moderately severe insomnia.


Loracarbef is an antibiotic. Its use was discontinued in 2006. It is a carbacephem, but it is sometimes grouped together with the second-generation cephalosporin antibiotics. It is a synthetic "carba" analogue of cefaclor, and is more stable chemically. Diarrhea is the most common adverse effect with loracarbef.


Loratadine is a second-generation antihistamine drug used to treat allergies. Structurally, it is closely related to tricyclic antidepressants such as imipramine, and distantly related to the atypical antipsychotic quetiapine. It is available as a generic drug and is marketed for its non-sedating properties. In combination with pseudoephedrine it is useful for colds as well as allergies, but adds potential side-effects of insomnia, nervousness, and anxiety.

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Lorcainide is a class 1c antiarrhythmic agent. It was discovered at Janssen Pharmaceutica in 1968.


Lorcaserin is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic.

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Lorglumide is a drug which inhibits gastrointestinal motility and reduces gastric secretions, acting as a cholecystokinin antagonist, with fairly high selectivity for the CCKA subtype. It has been suggested as a potential treatment for a variety of gastrointestinal problems including stomach ulcers, irritable bowel syndrome, dyspepsia, constipation and pancreatitis, as well as some forms of cancer, but animal and human testing has produced inconsistent results and no clear therapeutic role has been established, although it is widely used in scientific research.

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