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Selumetinib

Selumetinib is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells.

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Seratrodast

Seratrodast is a thromboxane receptor antagonist used primarily in the treatment of asthma.

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Sevoflurane

Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia.Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase and also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor, and the glycine receptor.

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Sibutramine

Sibutramine is an oral anorexiant. Until recently it was marketed and prescribed as an adjunct in the treatment of exogenous obesity along with diet and exercise. It has been associated with increased cardiovascular events and strokes and has been withdrawn from the market in the United States, the UK, the EU, Australia, Canada, Hong Kong, Thailand and Mexico and recently in India following the decision of an expert committee on its effects on CVS. It is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines, although its mechanism of action is distinct. It was launched and marketed by Knoll Pharmaceuticals.

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Silfar SE 4

Silfar SE 4 is a silicone antifoam emulsion. It is recommended for the food and pharmaceutical sectors, fermentation processes and agrochemical formulations.

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Simvastatin

Simvastatin is a derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. The 6-membered lactone ring of simvastatin is hydrolyzed in vivo to generate mevinolinic acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

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Sitagliptin

Sitagliptin offered by ATK Chemical Company Limited, a best quality sitagliptin supplier is classified as antidiabetic drug treatment of diabetes mellitus type 2. Our product works by inhibiting the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme-inhibiting sitagliptin drug is used either alone or in combination with other oral antihyperglycemic agents. Buy sitagliptin online from us the best price.

 

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Spiradoline

Spiradoline is a drug which acts as a highly selective κ-opioid agonist. It has analgesic, diuretic and antitussive effects, and produces subjective effects in animals similar to those of ketocyclazocine and allylnormetazocine. The main effect in humans is sedation, along with analgesic and diuretic effects, but significant side effects such as dysphoria and hallucinations have stopped it from being used clinically. Kappa-agonists have been shown to react negatively with the Mu-receptor, instead of having an assumed synergy since they are both opiate receptors, such as with the Mu and Delta receptors.

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Stiripentol

Stiripentol is an anticonvulsant drug used in the treatment of epilepsy. It is unrelated to other anticonvulsants and belongs to the group of aromatic allylic alcohols.

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Succinimide

Succinimide is a cyclic imide. Succinimides are used as anticonvulsant drugs, including ethosuximide, phensuximide, and methsuximide. These are also used to form covalent bonds between proteins or peptides and plastics.

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