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SEW2871 analytical pure 98%

SEW2871 is a potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. Activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.

VX-765 analytical pure 0.99

VX-765 is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM in a cell-free assay.

WZ811 analytical pure 0.989

WZ811 is a small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM.

AT9283 analytical pure 0.996

AT9283 is a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl (T315I), JAK2 and JAK3, Aurora A and Aurora B, respectively.

AZ3451 analytical pure 0.985

AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.

AZD1480 analytical pure 0.99

AZD1480 is a selective ATP-competitive JAK1/2 inhibitor with IC50 value of 1.3 and <0.4 nM, respectively, as well as shows inhibitory effect on JAK3 and Tyk2.

AZD3264 analytical pure 0.99

AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.

BGJ398 analytical pure 0.996

BGJ-398 is a selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively and > 40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.

BIBF0775 analytical pure 97%

BIBF0775 is an inhibitor of transforming growth factor β receptor I (TGFβRI) by soaking into the kinase domain of TGFβRI.

BLZ945 analytical pure 0.999

BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM and > 3200-fold higher than its affinity for other kinases.

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