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Retigabine

Retigabine is an anticonvulsant used as a treatment for partial epilepsies. Retigabine appears to be free of drug interactions with most commonly used anticonvulsants. It may increase metabolism of lamotrigine (Lamictal), whereas phenytoin (Dilantin) and carbamazepine (CBZ, Tegretol) increase the clearance of retigabine. Retigabine acts as a neuronal KCNQ/Kv7 potassium channel opener, a mechanism of action markedly different from than of any current anticonvulsants.

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Riboflavin

Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals. It is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. It is widely used as food and feed additives. Riboflavin has been used in several clinical and therapeutic situations. It has also been used as a muscle pain reliever. Because riboflavin is fluorescent under UV light, dilute solutions are often used to detect leaks or to demonstrate coverage in an industrial system such as chemical blend tank or bioreactor.

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Rimonabant

Rimonabant is an anorectic antiobesity drug that has been withdrawn from the market. It is an inverse agonist for the cannabinoid receptor CB1. Its main effect is reduction in appetite.

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RolanMICRO

RolanMICRO is widely used in pharmaceutical & cosmetic ointments & creams, superior adhesive tapes etc.

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Ropinirole

Ropinirole is a non-ergoline dopamine agonist. It is used in the treatment of Parkinson's disease.It is also used for the treatment of restless legs syndrome.Ropinirole can cause nausea, dizziness, hallucinations, orthostatic hypotension, and sudden sleep attacks during the daytime.

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Roquinimex

Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity. It also inhibits angiogenesis and reduces the secretion of TNF alpha. It has been investigated as a treatment for some cancers and autoimmune diseases, such as multiple sclerosis and recent-onset type I diabetes. Several trials have been terminated due to serious cardiovascular toxicity.

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Rotigotine

Rotigotine is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease and restless legs syndrome in Europe and the United States. Like other dopamine agonists, rotigotine has been shown to possess antidepressant effects and may be useful in the treatment of depression as well.

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Rufigallol

Rufigallol is an organic compound. It can be obtained by treating gallic acid with concentrated sulfuric acid and then with sodium hydroxide. It is particularly toxic to the malarial parasite Plasmodium falciparum and has a synergistic effect in combination with the antimalarial drug exifone, which has structural similarities to rufigallol. Rufigallol forms a crimson-colored complex with beryllium, aluminum, thorium, zirconium and hafnium, and this reaction has been used for the spot and spectrophotometric determination of beryllium in low concentrations.

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STRYCHNINE

Strychnine is a highly toxic, colorless, bitter crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. The first total synthesis of strychnine was reported by the research group of R. B. Woodward in 1954. Strychnine, when inhaled, swallowed, or absorbed through eyes or mouth, causes a poisoning which results in muscular convulsions and eventually death through asphyxia. Strychnine was popularly used as an athletic performance enhancer and recreational stimulant in the late 19th century and early 20th century, due to its convulsant effects. It was thought to be similar to coffee.Strychnine poisoning in animals usually occurs from ingestion of baits designed for use against gophers, moles, and coyotes. Strychnine is also used as a rodenticide, but is not specific to such unwanted pests and may kill other small animals.Strychnine toxicity in rats is dependent on sex. It is more toxic to females than to males when administered via subcutaneous injection or intraperitoneal injection.Strychnine is rapidly metabolized by the liver microsomal enzyme system requiring NADPH and O2. Strychnine competes with the inhibitory neurotransmitter glycine resulting in an excitatory state. However, the toxicokinetics after overdose have not been well described. In most severe cases of strychnine poisoning, the patient dies before reaching the hospital. The biological half-life of strychnine is about 10 hours.

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Salicylate

Salicylate is a salt or ester of salicylic acid.Salicylatesclass of drugs has analgesic,antipyretic and anti-inflammatory properties.It reduces the pain and inflammation associated with rheumatoid arthritis.

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