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STRYCHNINE

Strychnine is a highly toxic, colorless, bitter crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. The first total synthesis of strychnine was reported by the research group of R. B. Woodward in 1954. Strychnine, when inhaled, swallowed, or absorbed through eyes or mouth, causes a poisoning which results in muscular convulsions and eventually death through asphyxia. Strychnine was popularly used as an athletic performance enhancer and recreational stimulant in the late 19th century and early 20th century, due to its convulsant effects. It was thought to be similar to coffee.Strychnine poisoning in animals usually occurs from ingestion of baits designed for use against gophers, moles, and coyotes. Strychnine is also used as a rodenticide, but is not specific to such unwanted pests and may kill other small animals.Strychnine toxicity in rats is dependent on sex. It is more toxic to females than to males when administered via subcutaneous injection or intraperitoneal injection.Strychnine is rapidly metabolized by the liver microsomal enzyme system requiring NADPH and O2. Strychnine competes with the inhibitory neurotransmitter glycine resulting in an excitatory state. However, the toxicokinetics after overdose have not been well described. In most severe cases of strychnine poisoning, the patient dies before reaching the hospital. The biological half-life of strychnine is about 10 hours.

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Salicylate

Salicylate is a salt or ester of salicylic acid.Salicylatesclass of drugs has analgesic,antipyretic and anti-inflammatory properties.It reduces the pain and inflammation associated with rheumatoid arthritis.

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Salubrinal

Salubrinal is a drug which acts as a specific inhibitor of eIF2α phosphatase enzymes and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. It indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit, resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. It has putative therapeutic value due to its function, but is as yet only used experimentally.

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Saquinavir

Saquinavir is an antiretroviral drug used in HIV therapy. It falls in the protease inhibitor class.Saquinavir was the first protease inhibitor (and sixth antiretroviral) approved by the Food and Drug Administration (FDA). It was approved on December 6, 1995.Saquinavir is in a class of antiviral medications called protease inhibitors. It works by slowing the spread of HIV in the body. Saquinavir does not cure HIV and may not prevent you from developing HIV-related illnesses. Saquinavir does not prevent the spread of HIV to other people.

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Saredutant

Saredutant is a drug which acts as a NK2 receptor antagonist. It was under development by Sanofi-Aventis as a novel antidepressant and anxiolytic and made it to phase III clinical trials. However, in May 2009, Sanofi-Aventis published its quarterly results and announced the cessation of 14 research and development projects, among which was saredutant for the treatment of major depressive disorder.

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Sarmazenil

Sarmazenil is a drug from the benzodiazepine family. It acts as a partial inverse agonist of benzodiazepine receptors, meaning that it causes the opposite effects to most benzodiazepine drugs, and instead acts as an anxiogenic and convulsant. It is used in veterinary medicine to reverse the effects of benzodiazepine sedative drugs in order to rapidly re-awaken anaethetised animals.

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Semorphone

Semorphone is an opiate analogue that is an N-substituted derivative of oxymorphone. It is a partial agonist at μ-opioid receptors. It is around twice the potency of morphine, but with a ceiling effect on both analgesia and respiratory depression which means that these effects stop becoming any stronger after a certain maximum dose.

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Sertindole

Sertindole is an antipsychotic medication. It was developed by the Danish pharmaceutical company H. Lundbeck and marketed under license by Abbott Labs. Like other atypical antipsychotics, it has activity at dopamine and serotonin receptors in the brain. It is used in the treatment of schizophrenia. It is classified chemically as a phenylindole derivative.

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Sertraline

Sertraline is a selective serotonin uptake inhibitor that is used in the treatment of depression.It is believed that sertraline inhibits reuptake of serotonin at the neuronal membrane. SSRIs have less sedative, anticholinergic, and cardiovascular effects than the tricyclic antidepressant drugs because of decreased binding to histamine, acetylcholine, and norepinephrine receptors.Symptoms of toxicity include alopecia, decreased libido, diarrhea, ejaculation disorder, fatigue, insomnia, somnolence and serotonin syndrome

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Setazindol

Setazindol is an anorectic. It was never marketed.

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