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Turbuhaler

Turbuhaler is an inspiratory flow-driven, multidose dry-powder inhaler that is easy to use and has an extensive clinical documentation in respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). It offers high lung deposition of various inhaled drugs, with minimal delivery to unwanted areas, e.g. the mouth and pharynx. It features a multidose system that is preloaded, easily handled, and does not require coordination between actuation and inhalation. Turbuhaler was designed specifically to eliminate the need for propellants (e.g. CFCs).

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Usnic Acid

Usnic acid is a naturally occurring dibenzofuran derivative found in several lichen species. It was first isolated by German scientist W. Knop in 1844 and first synthesized between 1933-1937 by Curd and Robertson. Lichen extracts containing usnic acid have been utilized in medicine, perfumery, cosmetics, and ecology.

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Valdecoxib

Valdecoxib is classified as a nonsteroidal anti-inflammatory drug (NSAID) .It is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, rheumatoid arthritis, dysmenorrhoea and painful menstruation and menstrual symptoms. It is a cyclooxygenase-2 selective inhibitor.

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Valrubicin

Valrubicin is a chemotherapy drug used to treat bladder cancer. It is a semisynthetic analog of the anthracycline doxorubicin, and is administered by infusion directly into the bladder.

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Vancomycin

Vancomycin is useful for R&D Purpose.

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Vandetanib

Vandetanib is an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability.

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Vardenafil

Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).Symptoms of overdose include vision changes and back and muscle pain.

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Vigabatrin

Vigabatrin is an analogue of gamma-aminobutyric acid. It is an irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid.Vigabatrin, is an anticonvulsant chemically unrelated to other anticonvulsants.It inhibits the catabolism of GABA. It is an analog of GABA, but it is not a receptor agonist. Vigabatrin irreversibly inhibits the enzyme GABA transaminase.It increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA (gamma-aminobutyric acid transaminase GABA-T) or block the reuptake of GABA into glia and nerve endings. Vigabatrin may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

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Vilazodone

Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT receptors. It has been shown to be equally efficacious as other antidepressants with similar gastrointestinal side effects and possibly with reduced sexual side effects and weight gain. Vilazodone is an antidepressant agent that can used as an alternative for patients who cannot tolerate therapy with other antidepressant classes such as selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors. Treatment should be titrated towards the target dose, which is 40mg per day.Vilazodone increases serotonin levels in the brain by inhibiting the reuptake of serotonin while acting as a partial agonist on serotonin-1A receptors. It has therefore been coined by scientists as a selective partial agonist and reuptake inhibitor (SPARI).

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Vismodegib

Vismodegib is a small, orally administrable molecule, belonging to the 2-arylpyridine class, which was discovered by Genentech Inc under a collaboration with Curis Inc. Vismodegib inhibits the Hedgehog (Hh) pathway, which is involved in tumorigenesis, thus providing a strong rationale for its use in the treatment of a variety of cancers. Vismodegib suppresses Hh signaling by binding to and interfering with smoothened, a membrane protein that provides positive signals to the Hh signaling pathway.Vismodegib is currently undergoing phase II clinical trials for the treatment of advanced BCC, metastatic colorectal cancer, ovarian cancer, MB and other solid tumors.

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