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Vilazodone

Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT receptors. It has been shown to be equally efficacious as other antidepressants with similar gastrointestinal side effects and possibly with reduced sexual side effects and weight gain. Vilazodone is an antidepressant agent that can used as an alternative for patients who cannot tolerate therapy with other antidepressant classes such as selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors. Treatment should be titrated towards the target dose, which is 40mg per day.Vilazodone increases serotonin levels in the brain by inhibiting the reuptake of serotonin while acting as a partial agonist on serotonin-1A receptors. It has therefore been coined by scientists as a selective partial agonist and reuptake inhibitor (SPARI).

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Vismodegib

Vismodegib is a small, orally administrable molecule, belonging to the 2-arylpyridine class, which was discovered by Genentech Inc under a collaboration with Curis Inc. Vismodegib inhibits the Hedgehog (Hh) pathway, which is involved in tumorigenesis, thus providing a strong rationale for its use in the treatment of a variety of cancers. Vismodegib suppresses Hh signaling by binding to and interfering with smoothened, a membrane protein that provides positive signals to the Hh signaling pathway.Vismodegib is currently undergoing phase II clinical trials for the treatment of advanced BCC, metastatic colorectal cancer, ovarian cancer, MB and other solid tumors.

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Vitasmooth

Vitasmooth is a highly compactable and organoleptically pleasing formulation of calcium carbonate specifically designed for incorporation into nutritional supplements. Vitasmooth is ideal for the formulation of both calcium and calcium and vitamin supplements manufactured by direct compression.

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Vorinostat

Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new class of agents known as histone deacetylase inhibitors. A recent study suggested that vorinostat also possesses.

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Xipranolol

Xipranolol is a beta blocker.

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Zatosetron

Zatosetron is a drug which acts as an antagonist at the 5HT3 receptor. It is orally active and has a long duration of action, producing antinauseant effects but without stimulating the rate of gastrointestinal transport. It is also an effective anxiolytic in both animal studies and human trials, although with some side effects at higher doses.

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Zestoretic

Zestoretic combines an angiotensin converting enzyme inhibitor, lisinopril, and a diuretic, hydrochlorothiazide. It was sustained for at least 24 hours. Zestoretic is indicated for the treatment of hypertension.

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Zidovudine

Zidovudine is a nucleoside analog reverse transcriptase inhibitor, a type of antiretroviral drug used for the treatment of HIV/AIDS. It is an analog of thymidine.It is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.Zidovudine is phosphorylated to active metabolites that compete for incorporation into viral DNA and inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis.The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

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Zometapine

Zometapine is an antidepressant drug which is a pyrazolodiazepine derivative. Its molecular structure closely resembles benzodiazepines and is unrelated to other antidepressant drug classes.

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