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Alaproclate

Alaproclate is a psychoactive drug and research chemical that was being developed as an antidepressant by the Swedish pharmaceutical company Astra AB (now AstraZeneca) in the 1970s. It acts as a selective serotonin reuptake inhibitor, and along with zimelidine and indalpine, was one of the first of its kind. Development was discontinued due to the observation of liver complications in rodent studies. Some studies have found that it acts as a noncompetitive NMDA antagonist, but does not have discriminative stimulus properties similar to phencyclidine.

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Aleglitazar

Aleglitazar is a peroxisome proliferator-activated receptor agonist with affinity to PPARα and PPARγ, which is being developed for the treatment of type II diabetes. It is currently in phase II clinical trials.

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Alfatradiol

Alfatradiol is a 5α-reductase inhibitor used topically for the treatment of androgenic alopecia in men and women. It is used in form of an ethanolic solution for topical application on the scalp.

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Allopurinol

Allopurinol is a drug used primarily to treat hyperuricemia and its complications, including chronic gout. The primary use of allopurinol is to treat hyperuricemia and its complications. It does not alleviate acute attacks of gout, but is useful in chronic gout to prevent future attacks. Likewise, allopurinol commonly is used as prophylaxis with chemotherapeutic treatments, which can rapidly produce severe hyperuricemia. Other established indications for allopurinol therapy include ischemic reperfusion injury, kidney stones with a uric acid component, and protozoal infections. Because allopurinol is not a uricosuric, it can be used in patients with poor kidney function. A recent study has suggested that allopurinol can help reduce the effects of angina in ischaemic heart disease by reducing the workload on the heart.

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Alnespirone

Alnespirone is a selective 5-HT1A receptor full agonist of the azapirone chemical class. It has antidepressant and anxiolytic effects.

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Alprenoxime

Alprenoxime is a beta blocker. It is a prodrug to alprenolol.

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Amarogentin

Amarogentin is a naturally occurring secoiridoid glycoside.It is a phenol carbonic acid ester of sweroside, a substance related to gentiopicrin.It is rich in natural sugar and is beneficial for the pancreas, spleen and kidneys.Its main use is as a digestive tonic and also used in antismoking formulae and tonics.

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Amisulpride

Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. In small doses it is also used to treat depression.

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Amobarbital

Amobarbital is a drug that is a barbiturate derivative. It has sedative-hypnotic properties. It is a white crystalline powder with no odor and a slightly bitter taste. It was first synthesized in Germany in 1923.Amobarbital dependence mimics delirium tremens and may be life-threatening. Amobarbital has been used in a study to inhibit mitochondrial electron transport in the rat heart. It has an LD50 in mice of 212 mg/kg s.c. Amobarbital has been known to decrease the effects of hormonal birth control, sometimes to the point of uselessness.

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Amodiaquine

Amodiaquine is a 4-aminoquinoline compound related to chloroquine, used as an antimalarial and anti-inflammatory agent. It is a histamine N-methyltransferase inhibitor. It has been shown to be more effective than chloroquine in treating CRPF malaria infections and may afford more protection than chloroquine when used as weekly prophylaxis.

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