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Elesclomol

Elesclomol is a drug that triggers apoptosis in cancer cells. It induces oxidative stress by provoking a buildup of reactive oxygen species within cancer cells.

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Eletriptan

Eletriptan is a second generation triptan drug intended for treatment of migraine headaches. It is used as an abortive medication, blocking a migraine attack which is already in progress.Eletriptan works in the brain to relieve the pain from migraine headaches. It belongs to the group of medicines called triptans.Eletriptan is believed to reduce swelling of the blood vessels surrounding the brain.

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Elfazepam

Elfazepam is a drug which is a benzodiazepine derivative. Presumably it has sedative and anxiolytic actions like those of other benzodiazepines. It has appetite stimulating properties in animals. The mechanism for increasing feed intake is not clear and has been subject of investigation. It has been found that elfazepam suppresses gastric acid secretion.

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Eliprodil

Eliprodil is a drug which acts as an NMDA antagonist, binding to the polyamine modulatory site. It has neuroprotective and anticonvulsant effects in animal studies, but does not support self administration or substitute for phencyclidine, and does not produce sedation or amnesia. It was researched for the treatment of stroke and epilepsy but human trials failed to show clear beneficial effects.

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Elsamitrucin

Elsamitrucin is a drug used in chemotherapy.

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Elvitegravir

Elvitegravir is an investigational new drug for the treatment of HIV infection. It acts as an integrase inhibitor. It is undergoing Phase III clinical trial conducted by the pharmaceutical company Gilead Sciences, which licensed EVG from Japan Tobacco in March 2008.

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Emetine

Emetine is a drug used as both an anti-protozoal and to induce vomiting. It is produced from the ipecac root.

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Emtricitabine

Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Emtricitabine is an analogue of cytidine. Emtricitabine helps to block HIV reverse transcriptase, a chemical in your body (enzyme) that is needed for HIV to multiply. Emtricitabine is always used with other anti-HIV medicines to treat people with HIV infection. Emtricitabine may lower the amount of HIV in the blood (viral load). Emtricitabine may also help to increase the number of T cells called CD4 cells. Emtricitabine works by inhibiting reverse transcriptase, the enzyme that copies HIV RNA into new viral DNA. It is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate, which is responsible for the inhibition of HIV-1 reverse transcriptase. It competes with the natural substrate deoxycytidine 5'-triphosphate and incorporates into nascent viral DNA, resulting in early chain termination. Therefore emtricitabine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate deoxycytidine 5'-triphosphate and by its incorporation into viral DNA. By inhibiting HIV-1 reverse transcriptase, emtricitabine can help to lower the amount of HIV.

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Enalapril

Enalapril is one of the angiotensin-converting enzyme inhibitors that is used to treat hypertension.Enalaprilat blocks the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Enalaprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

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Enalaprilat

Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril.

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