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Dacomitinib

Dacomitinib is an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

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Deferasirox

Deferasirox is a rationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias. It is the first oral medication approved in the USA for this purpose.

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Deferiprone

Deferiprone is a drug that chelates iron and is used to treat thalassaemia major.Deferiprone compound belongs to the class of organic compounds known as methylpyridines.

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Demecolcine

Demecolcine is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl.

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Deserpidine

Deserpidine is an antihypertensive drug related to reserpine.

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Dexanabinol

Dexanabinol is a synthetic cannabinoid derivative, which is the "unnatural" enantiomer of the potent cannabinoid agonist HU-210. Unlike other cannabinoid derivatives, it does not act as a cannabinoid receptor agonist, but instead has NMDA antagonist effects. It therefore does not produce cannabis-like effects, but is anticonvulsant and neuroprotective, and is widely used in scientific research as well as currently being studied for practical applications such as treatment of head injury or stroke. However, in clinical trials it was shown to be safe, but not more efficacious than placebo.

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Dextrorphan

Dextrorphan is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextro-stereoisomer of racemorphan, the levo-half being levorphanol. It is produced by O-demethylation of dextromethorphan by CYP2D6. It is an NMDA antagonist and contributes to the abuse liability of dextromethorphan.

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Dinapsoline

Dinapsoline is a drug developed for the treatment of Parkinson's disease, that acts as a selective full agonist at the dopamine D1 receptor.

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Domperidone

Domperidone is an antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting. It has also been used to stimulate lactation.Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting.It can be used in patients with Parkinson's disease.Domperidone has also been found effective in the treatment of gastroparesis stomach motility condition, and for paediatric gastroesophageal reflux (infant vomiting).

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Dorzolamide

Dorzolamide is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. This drug, developed by Merck, was the first drug in human therapy which resulted from structure-based drug design.

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