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SH-4-54 analytical pure 0.99

SH-4-54 is a potent, small molecule, nonphosphorylated STAT3 inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.

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SMI-4a analytical pure 0.996

SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.

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VE-821 analytical pure 0.994

VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.

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VE-822 analytical pure 0.999

VE-822 is an ATR inhibitor with IC50 of 19 nM in HT29 cells.

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Yoda 1 analytical pure 0.999

Yoda 1 is a Piezo1 channel activator.

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ABT-199 analytical pure 0.999

ABT-199 is a Bcl-2-selective inhibitor with Ki of < 0.01 nM, > 4800-fold selective versus Bcl-xL and Bcl-w, and showing no activity to Mcl-1.

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ABT-263 analytical pure 0.993

ABT-263 is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1.

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AZD0156 analytical pure 0.999

AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.

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AZD1080 analytical pure 0.999

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows > 14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

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AZD1208 analytical pure 0.998

AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases (IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively) and is used for treating AML.

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