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Finasteride

Finasteride is a synthetic antiandrogen that acts by inhibiting type II 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT). It is used in the treatment of benign prostatic hyperplasia (BPH), and male pattern baldness (MPB).

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Florfenicol

Florfenicol is a fluorinated synthetic analog of thiamphenicol. In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida, and Haemophilus somnus, for treatment of bovine interdigital phlegmon associated with Fusobacterium necrophorum and Bacteroides melaninogenicus. The use of florfenicol in horses, and likely in other equids, typically causes diarrhea.

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Fluconazole

Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.Fluconazole is indicated for the treatment and prophylaxis of fungal infections where other antifungals have failed or are not tolerated (e.g., due to adverse effects).Fluconazole can be used first-line for the Coccidioidomycosis, Cryptococcosis, HistoplasmosisFluconazole is secreted in human milk at concentrations similar to plasma.Fluconazole can be synthesized from a halogenated acetophenone derivative.

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Flucytosine

Flucytosine is a toxic antifungal/antimicrobial agent.It is also used as pharma intermediate.

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Fludarabine

Fludarabine is a chemotherapy drug used in the treatment of hematological malignancies. Fludarabine is highly effective in the treatment of chronic lymphocytic leukemia, producing higher response rates than alkylating agents such as chlorambucil alone. Fludarabine is used in various combinations with cyclophosphamide, mitoxantrone, dexamethasone and rituximab in the treatment of indolent non-Hodgkins lymphomas. Fludarabine is a purine analog, and can be given both orally and intravenously. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. It is active against both dividing and resting cells. Fludarabine is associated with profound lymphopenia, and as a consequence, increases the risk of opportunistic infections significantly. Fludarabine causes anemia, thrombocytopenia and neutropenia.

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Fludiazepam

Fludiazepam is a drug which is a benzodiazepine derivative and is closely related to diazepam. It exerts its pharmacological properties via enhancement of GABAergic inhibition. It has 4 times more binding affinity for benzodiazepine receptors than diazepam. It possesses anxiolytic, anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties.

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Fluvoxamine

Fluvoxamine is an antidepressant which functions as a selective serotonin reuptake inhibitor (SSRI). Fluvoxamine was first approved by the U.S. Food and Drug Administration (FDA) in 1993 for the treatment of obsessive compulsive disorder (OCD).Fluvoxamine has been found to be useful in the treatment of major depressive disorder (MDD), and anxiety disorders such as panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), and obsessive-compulsive spectrum disorders. Fluvoxamine is indicated for children and adolescents with OCD. Fluvoxamine is a potent and selective serotonin reuptake inhibitor with approximately 100-fold affinity for the serotonin transporter over the norepinephrine transporter. It has negligible affinity for the dopamine transporter or any other receptor, with the sole exception of the σ1 receptor. It behaves as a potent agonist at this receptor.

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Formebolone

Formebolone is an anabolic steroid. It is used as a muscle inflammatory. It will inflame a local injection site and cause the muscle to gain size temporarily.

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Fotemustine

Fotemustine is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma. A study has shown that fotemustine produces improved response rates and increased survival over dacarbazine in the treatment of disseminated cutaneous melanoma.

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Fulvestrant

Fulvestrant is a drug treatment of hormone receptor-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor. Fulvestrant competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. First, fulvestrant binds to the receptors and downregulates them so that estrogen is no longer able to bind to these receptors. Second, fulvestrant degrades the estrogen receptors to which it is bound. Both of these mechanisms inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer cell lines.

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