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Lortalamine is an antidepressant which was synthesized in the early 1980s. It acts as a potent and highly selective norepinephrine reuptake inhibitor. It was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals. It has been used to label the norepinephrine transporter in positron emission tomography studies.
Lumiracoxib is a COX-2 selective inhibitor non-steroidal anti-inflammatory drug, manufactured by Novartis. It has several distinctive features. Its structure is different from that of other COX-2 inhibitors, such as celecoxib. It is an analogue of diclofenac, making it a member of the arylalkanoic acid class of NSAIDs. It binds to a different site on the COX-2 receptor than do other COX-2 inhibitors. It is the only acidic coxib and has the highest COX-2 selectivity of any NSAID. Since its original approval, lumiracoxib has been withdrawn from the market in several countries, mostly due to hepatotoxicity concerns. It has never been approved for use in the United States.
Mebendazole is a benzimidazole drug. It is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.
Mepiprazole is a minor tranquilizer with a phenylpiperazine structure used for the treatment of anxiety neuroses. It acts as a 5-HT2 and α1-adrenergic receptor antagonist, and has also been shown to inhibit the reuptake and induce the release of serotonin, dopamine, and norepinephrine to varying extents. Similarly to other phenylpiperazines like trazodone, nefazodone, and etoperidone, mepiprazole produces mCPP as an active metabolite.
Mepivacaine is a local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia and anesthesia by local infiltration, peripheral nerve block techniques. Mepivacaine is effective topically only in large doses and therefore should not be used by this route.
Meprobamate is a tranquilizing drug that acts as a depressant of the central nervous system and is commonly used in the treatment of anxiety and sometimes schizophrenia. Although meprobamate is chemically unlike barbiturates and has lower toxicity, it has similar pharmacological effects, especially the ability to induce sleep and alleviate anxiety. The drug possesses some anticonvulsant properties and is used to suppress some forms of epilepsy. A muscle relaxant, meprobamate is also used to treat abnormal motor activity.
Meprylcaine is a local anesthetic.
Mesterolone is an orally applicable androgen, and DHT derivative. Mesterolone belongs to the group of medicines known as androgens which are male hormones. It can be used to treat disorders in men where the body does not produce enough natural androgen. It works by supplementing the amount of androgen naturally produced.
Methimazole is an antithyroid drug, and part of the thioamide group.
Methylamine is the organic compound. This colourless gas is a derivative of ammonia, where in one H atom is replaced by a methyl group. It is the simplest primary amine. It has a strong odor similar to fish. Methylamine is used as a building block for the synthesis of many other commercially available compounds. Representative commercially significant chemicals produced from methylamine include the pharmaceuticals ephedrine and theophylline, the pesticides carbofuran, carbaryl, and metham sodium, and the solvents N-methylformamide and N-methylpyrrolidone. The preparation of some surfactants and photographic developers require methylamine as a building block. Liquid methylamine can be used as a solvent analogous to liquid ammonia. It can also be used for scavenging H2S from hydrocarbon in refining applications.
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