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Penfluridol

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and fluspirilene, penfluridol has an extremely long elimination half-life and its effects last for many days after single oral dose. Its antipsychotic potency, in terms of dose needed to produce comparable effects, is similar to both haloperidol and pimozide. It is only slightly sedative, but often causes extrapyramidal side-effects, such as akathisia, dyskinesiae and pseudo-Parkinsonism. It is indicated for antipsychotic treatment of chronic schizophrenia and similar psychotic disorders, it is, however, like most typical antipsychotics, being increasingly replaced by the atypical antipsychotics.

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Pentazocine

Pentazocine is a synthetically-prepared prototypical mixed agonist-antagonist narcotic drug of the benzomorphan class of opioids used to treat moderate to moderately severe pain. This compound may exist as one of two enantiomers, named (+)-pentazocine and (-)-pentazocine. (-)-Pentazocine is a κ opioid receptor agonist, while (+)-pentazocine is not, instead displaying a ten-fold greater affinity for the σ receptor.

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Perchlorate

Perchlorate is used as a medicine to treat thyroid gland disorders.They are used extensively within the pyrotechnics industry.

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Perindopril

An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.The mechanism through which perindopril lowers blood pressure is believed to be primarily inhibition of angiotensin converting enzyme (ACE) activity.

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Phenazocine

Phenazocine is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects. Effects of phenazocine include analgesia and euphoria, also may include dysphoria and hallucinations at high doses, most likely due to action at κ-opioid and σ receptors. It appears to be a much stronger analgesic with fewer side effects than pentazocine, probably due to a more favorable μ and κ binding ratio.

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Phentermine

Phentermine is a psychostimulant drug of the phenethylamine class, with pharmacology similar to amphetamine. It is used medically as an appetite suppressant. Phentermine is used together with diet and exercise to treat obesity (overweight) in people with risk factors such as high blood pressure, high cholesterol, or diabetes. It is a central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse. Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain.

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Phycocyanin

Phycocyanin is a blue colored pigment that belongs to the class of Phycobilli proteins found in Blue-Green algae.Phycocyanin has found numerous applications in the pharmaceutical and food & beverage industry. It is used primarily in the latter as a natural coloring agent.More recently phycocyanin was found to have major potential as a fluorescent marker and as an antioxidant in the health industry.

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Phytic Acid

Phytic acid is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It may be considered a phytonutrient, providing an antioxidant effect. Phytic acid's mineral binding properties may also prevent colon cancer by reducing oxidative stress in the lumen of the intestinal tract. As a food additive, phytic acid is used as a preservative.

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Piceatannol

Piceatannol is a stilbenoid, a type of phenolic compound. It is a metabolite of resveratrol found in red wine. LMP2A, a viral protein-tyrosine kinase implicated in leukemia, non-Hodgkin's lymphoma and other diseases associated with Epstein-Barr virus, were found to be blocked by picetannol in vitro. Therefore there is research interest in piceatannol as an anti-cancer and anti-EBV drug.

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Piclamilast

Piclamilast is a selective PDE4 inhibitor. It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma. It is a second generation compound that exhibits structural functionalities of the PDE4 inhibitors cilomilast and roflumilast. The structure for piclamilast was first elucidated in a 1995 European patent application.

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