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VE-822 analytical pure 0.999

VE-822 is an ATR inhibitor with IC50 of 19 nM in HT29 cells.

Yoda 1 analytical pure 0.999

Yoda 1 is a Piezo1 channel activator.

ABT-199 analytical pure 0.999

ABT-199 is a Bcl-2-selective inhibitor with Ki of < 0.01 nM, > 4800-fold selective versus Bcl-xL and Bcl-w, and showing no activity to Mcl-1.

ABT-263 analytical pure 0.993

ABT-263 is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1.

AZD0156 analytical pure 0.999

AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.

AZD1080 analytical pure 0.999

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows > 14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

AZD1208 analytical pure 0.998

AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases (IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively) and is used for treating AML.

AZD2014 analytical pure 0.993

AZD2014 is an mTOR inhibitor with IC50 of 2.8 nM and is highly selective against multiple PI3K isoforms (α/β/γ/δ).

AZD5363 analytical pure 0.996

AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.

AZD6738 analytical pure 0.994

AZD6738 is a highly selective and potent inhibitor of ATR kinase activity with IC50 value of 1nM in isolated enzyme assay and showed inhibitory effect on ATR kinase-dependent cellular Chk1 phosphorylation with IC50 value of 74nM.

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