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AZD1208 analytical pure 0.998

AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases (IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively) and is used for treating AML.

AZD2014 analytical pure 0.993

AZD2014 is an mTOR inhibitor with IC50 of 2.8 nM and is highly selective against multiple PI3K isoforms (α/β/γ/δ).

AZD5363 analytical pure 0.996

AZD5363 is a potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.

AZD6738 analytical pure 0.994

AZD6738 is a highly selective and potent inhibitor of ATR kinase activity with IC50 value of 1nM in isolated enzyme assay and showed inhibitory effect on ATR kinase-dependent cellular Chk1 phosphorylation with IC50 value of 74nM.

AZD7762 analytical pure 0.999

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM, being equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.

AZD8186 analytical pure 0.999

AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).

Amitriptyline Hydrochloride

Amitriptyline Hydrochloride is an antidepressant with sedative effects. Its mechanism of action in man is not known. Amitriptyline Hydrochloride is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system.

BLU9931 analytical pure 0.999

BLU9931 is an inhibitor of FGFR4 with IC50 of 3 nM and is less potent for FGFR1/2/3 (IC50 > 150 nM).

BMN-673 analytical pure 0.999

BMN-673 is a PARP1/2 inhibitor with IC50 of 0.57 nM for PARP1.

BSI-201 analytical pure 0.978

BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC).

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