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Phytic Acid

Phytic acid is the principal storage form of phosphorus in many plant tissues, especially bran and seeds. It may be considered a phytonutrient, providing an antioxidant effect. Phytic acid's mineral binding properties may also prevent colon cancer by reducing oxidative stress in the lumen of the intestinal tract. As a food additive, phytic acid is used as a preservative.

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Piceatannol

Piceatannol is a stilbenoid, a type of phenolic compound. It is a metabolite of resveratrol found in red wine. LMP2A, a viral protein-tyrosine kinase implicated in leukemia, non-Hodgkin's lymphoma and other diseases associated with Epstein-Barr virus, were found to be blocked by picetannol in vitro. Therefore there is research interest in piceatannol as an anti-cancer and anti-EBV drug.

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Piclamilast

Piclamilast is a selective PDE4 inhibitor. It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma. It is a second generation compound that exhibits structural functionalities of the PDE4 inhibitors cilomilast and roflumilast. The structure for piclamilast was first elucidated in a 1995 European patent application.

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Picloxydine

Picloxydine is a bisbiguanide antiseptic used in eye drops. It is structurally similar to chlorhexidine.

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Pilocarpine

Pilocarpine is a parasympathomimetic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at the muscarinic acetylcholine receptor M3 due to its topical application.

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Piperaquine

Piperaquine is an antimalarial drug, a bisquinoline first synthesised in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. However, Chinese scientists discovered that piperaquine was suitable for artemisinin combination therapies.

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Piperocaine

Piperocaine is a local anesthetic drug used as its hydrochloride salt for infiltration and nerve blocks.

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Pirarubicin

Pirarubicin is an anthracycline drug. It intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.

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Pirfenidone

Pirfenidone is a drug used for the treatment of idiopathic pulmonary fibrosis (IPF).Pirfenidone is administered orally. Pirfenidone has well-established antifibrotic and anti-inflammatory properties in various in vitro systems and animal models of fibrosis. Pirfenidone has also been shown to reduce production of inflammatory mediators such as TNF-α and IL-1β in both cultured cells and isolated human peripheral blood mononuclear cells. Pirfenidone is frequently associated with gastrointestinal side effects such as dyspepsia, nausea, gastritis, gastroesophageal reflux disease (GERD) and vomiting. Pirfenidone is known to cause photosensitivity reactions, rash, pruritus and dry skin, increases hepatic enzyme levels.

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Pirisudanol

Pirisudanol is the succinic acid ester of pyridoxine and of deanol. It has been used in Europe in the treatment of mild cognitive impairment as well as fatigue and depression.

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