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AZD1152-HQPA is an active metabolite of Barasertib which is a novel acetanilide-substituted pyrazole-aminoquinazoline prodrug that is converted rapidly to the active drug AZD-1152 hydroxy-QPA (AZD1152-HQPA) in human plasma. AZD1152-HQPA is a specific inhibitor of the enzymatic activity of Aurora kinase, with selectivity for Aurora B (IC50 of 0.37 nM versus 1368 nM for Aurora B and A kinases, respectively); the inhibitor had even less activity against a panel of greater than 50 other serine-threonine and tyrosine kinases including FLT3, JAK2, and Abl.
Acenaphthene is a polycyclic aromatic hydrocarbon (PAH) consisting of naphthalene with an ethylene bridge connecting positions 1 and 8. An alternative name, 1,2-dihydroacenaphthylene, emphasizes that it is a hydrogenated form of acenaphthylene. It is a constituent of coal tar.Acenaphthene was prepared the first time from coal tar by Marcellin Berthelot and after that with Bardy he synthesized it from a-ethyl naphthalene. It is used in preparation of dyes, pesticides and pharmaceuticals.It does not appear to be carcinogenic.
Acetophenone is the simplest aromatic ketone. It occurs naturally in many foods including apple, cheese, apricot, banana, beef, and cauliflower. This colourless, viscous liquid is a precursor to useful resins and fragrances. It is used to create fragrances that resemble almond, cherry, honeysuckle, jasmine, and strawberry. It is used in chewing gum. Being prochiral, acetophenone is also a popular test substrate for asymmetric transfer hydrogenation experiments. It is also commonly used as a flavouring in many cherry flavoured sweets and drinks. Acetophenone is a raw material for the synthesis of some pharmaceuticals.
Acebrophylline is a xanthine derivative is prescribed as a bronchodilator for the treatment of bronchial asthma and COPD in adults. Acebrophylline alter mucus gel secretion phase by lowering viscosity and increasing the serous gel phase. Acebrophylline inhibits intracellular phosphodiesterase associated with cAMP levels and facilitates bronchial muscles relaxation. Acebrophylline selectively inhibits phosphatidylcholine and phospholipase A, TNF-alpha and leukotrienes.
Albaconazole is a triazole antifungal. It has potential broad-spectrum activity.
Alfacalcidol is an analogue of vitamin D used for supplementation in humans and as a poultry feed additive.
Ambucetamide is an antispasmodic found to be particularly effective for the relief of menstrual pain. It was discovered in 1953 by Paul Janssen.
Amdinocillin is an extended-spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria. It is used primarily in the treatment of urinary tract infections, and has also been used to treat typhoid and paratyphoid fever.
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Androsterone (ADT) is a steroid hormone with weak androgenic activity. It is made in the liver from the metabolism of testosterone. Its beta-isomer is Epiandrosterone.Androsterone is often advertised as influencing human behavior, but there is little data to substantiate its use as a pheromone.
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