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Dimethocaine

Dimethocaine is a local anesthetic with stimulant properties that some studies have shown to be one-tenth the potency of cocaine. Anecdotal user reports indicate no euphoria and only mild stimulating effects. Other users fail to perceive of any recreational effects whatsoever. The drug however still presents strain on the cardiovascular systems, like cocaine, with the potential to induce tachycardia which could be problematic for those who continuously redose. Additional reports of respiratory arrest have been noted.

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Drospirenone

Drospirenone is a synthetic progestin that is an analog to spironolactone.As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic.Progestins such as drospirenone diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.

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Elsamitrucin

Elsamitrucin is a drug used in chemotherapy.

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Elvitegravir

Elvitegravir is an investigational new drug for the treatment of HIV infection. It acts as an integrase inhibitor. It is undergoing Phase III clinical trial conducted by the pharmaceutical company Gilead Sciences, which licensed EVG from Japan Tobacco in March 2008.

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Enilospirone

Enilospirone is a selective 5-HT1A receptor agonist of the azapirone class.

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Enzalutamide

Enzalutamide is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. It blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. It also induces tumour cell apoptosis, and has no agonist activity. Early preclinical studies also suggest that MDV3100 inhibits breast cancer cell growth.

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Eplivanserin

Eplivanserin was an experimental drug for the treatment of insomnia which was being developed by Sanofi Aventis. Sanofi Aventis announced in December 2009 that it was withdrawing its application for approval of eplivanserin from both the U.S. Food and Drug Administration and the European Medicines Agency.

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Eptifibatide

Eptifibatide is synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation.Eptifibatide was not lethal to rats, rabbits, or monkeys when administered by continuous intravenous infusion .

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Esomeprazole

Esomeprazole is a proton pump inhibitor which is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease and Zollinger-Ellison syndrome. It is the S-enantiomer of omeprazole. It is a proton pump inhibitor which reduces acid secretion through inhibition of ATPase in gastric parietal cells.Esomeprazole is combined with the antibiotics clarithromycin and amoxicillin in the 7-14 day eradication triple therapy for Helicobacter pylori.

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Esreboxetine

Esreboxetine is a selective norepinephrine reuptake inhibitor which was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia but failed to show significant benefit over currently available medications and was discontinued. It is the (+)-(S,S)-enantiomer of reboxetine and is even more selective in comparison.

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