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Ibogaine

Ibogaine is a naturally occurring psychoactive substance found in a number of plants, principally in a member of the Apocynaceae family known as iboga. Some countries have banned this substance that has hallucinogen effects but in other countries it is being used to treat addiction to opiates, methamphetamine and other drugs.

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Ibrutinib

Ibrutinib is an experimental drug candidate for the treatment of various types of cancer. It is an orally-administered, selective and covalent inhibitor of the enzyme Bruton tyrosine kinase (Btk).It has given good results in two phase II clinical trials.Ibrutinib has been reported to reduce CLL cell chemotaxis towards the chemokines CXCL12 and CXCL13, and inhibit cellular adhesion following stimulation at the B cell receptor.

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Ibuprofen

Ibuprofen is a nonsteroidal anti-inflammatory drug used for relief of symptoms of arthritis, fever, as an analgesic for pain, especially where there is an inflammatory component, and dysmenorrhea. It is known to have an antiplatelet effect, though it is relatively mild and short-lived when compared with aspirin or other better-known antiplatelet drugs.Ibuprofen also acts as a vasodilator, having been shown to dilate coronary arteries and some other blood vessels.

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Icariin

Icariin is a flavonol, a type of flavonoid. It is the prenyl acetylation of kaempferide 3,7-O-diglucoside. The compound is derived from several species of plants in the Epimedium family. Extracts from these plants are reputed to produce aphrodisiac effects, and are commonly used in Chinese herbal medicine to enhance erectile function, as well as for several other indications. It is thought that icariin is likely to be the primary active component of Epimedium extracts, as it has been shown to share several mechanisms of action with compounds used in Western medicine to treat impotence and improve sexual function. In particular, icariin has been demonstrated to act as a PDE5 inhibitor and to enhance the production of bioactive nitric oxide, as well as mimicking the effects of testosterone. It also shows antioxidant, antidepressant and nootropic effects in animal studies, as well as stimulating osteoblast activity in bone tissue which has been linked to a possible therapeutic role in the treatment of osteoporosis.

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Ichthammol

Ichthammol is a product of natural origin obtained in the first step by dry distillation of sulfur-rich oil shale. It is used in medicine as a remedy for treating some skin diseases, such as acne, eczema and psoriasis. It is commonly used in 10% or 20% concentrate ointment form as a drawing salve. However, it does not actually draw out foreign objects. It does soften skin over a boil or spot allowing it to come to a head sooner. It also decreases microorganisms in the area surrounding a skin condition.

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Iclazepam

Iclazepam is a drug which is a benzodiazepine derivative. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and is around the same potency as chlordiazepoxide. It is a derivative of nordazepam substituted with a cyclopropylmethoxyethyl group on the N1 nitrogen. Once in the body, iclazepam is quickly metabolised to nordazepam and its N-(2-hydroxyethyl) derivative, which are thought to be mainly responsible for its effects.

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Idarubicin

Idarubicin is an anthracycline antileukemic drug. It inserts itself into DNA and prevents DNA from unwinding by interfering with the enzyme topoisomerase II. It is an analog of daunorubicin, but the absence of a methoxy group increases its fat solubility and cellular uptake. It belongs to the family of drugs called antitumor antibiotics. It is currently combined with cytosine arabinoside as a first line treatment of acute myeloid leukemia.

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Idebenone

Idebenone is an experimental drug, initially developed by Takeda Pharmaceutical Company for the treatment of Alzheimer's disease and other cognitive defects. This has been met with limited success. The Swiss company Santhera Pharmaceuticals has started to investigate it for the treatment of neuromuscular diseases. As of May 2010, early clinical trials for the treatment of Friedreich's ataxia and Duchenne muscular dystrophy have been completed. Chemically, idebenone is an organic compound of the quinone family. It is also promoted commercially as a synthetic analog of coenzyme Q10.

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Idoxuridine

Idoxuridine is an anti-herpesvirus antiviral drug.It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing. Idoxuridine is used only topically due to cardiotoxicity.It was synthesized by William Prusoff in the late 1950s.Idoxuridine is mainly used topically to treat herpes simplex keratitis.

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Ifenprodil tartrate

Ifenprodil is a piperidine derivative with α-adrenoceptor blocking capabilities that is used as a vasodilator. It is an N-methyl-D-aspartate (NMDA) receptor antagonist with selective targeting of receptors that contain the NR2B subunit.

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