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Glycyrrhizin is the main sweet-tasting compound from liquorice root. It is 30 to 50 times as sweet as sucrose. Chemically, glycyrrhizin is a triterpenoid saponin glycoside of glycyrrhizic acid. Upon hydrolysis, the glycoside loses its sweet taste and is converted to the aglycone glycyrrhetinic acid plus two molecules of glucuronic acid. Although sweet, the taste sensation of glycyrrhizin is different from that of sugar. The sweetness of glycyrrhizin has a slower onset than sugar, and lingers in the mouth for some time. Unlike the artificial sweetener aspartame, glycyrrhizin maintains its sweetness under heating. Glycyrrhizin is used as a flavoring in some candies, pharmaceuticals, and tobacco products.
Griseofulvin is an antifungal drug that is administered orally. It is used both in animals and in humans, to treat fungal infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.
Halofantrine is a drug used to treat malaria. Its structure contains a substituted phenanthrene, and is related to the antimalarial drugs quinine and lumefantrine. It is only used to treat malaria. It is not used to prevent malaria because of the risk of toxicity and unreliable absorption.
Halometasone is a corticosteroid. It can be used as topical glucocorticoid drug which has a significant and rapid anti-inflammatory, anti-allergic, anti-itch, anti-exudative and anti-proliferative effect.
Heptanal or heptanaldehyde is an alkyl aldehyde with a strong fruity odor which is used as an ingredient in cosmetics, perfumes, and flavors. Industrially,Heptanal is used in the manufacture of 1-heptanol and ethyl heptanoate. It is also used in pharmaceutical.
Hydrastinine is a semisynthetic alkaloid from the hydrolysis of the alkaloid hydrastine, which was found naturally in small quantities in Hydrastis canadensis L. It was produced by oxidative splitting of hydrastine hydrochloride with nitric acid in good yield. The drug was patented by Bayer as a haemostatic drug during the 1910s.
Hydrotalcite is used in antacid medicine for gastric and duodenal ulcers, chronic gastritis compete, anti-reflux esophagitis influencing, used as a filler for plastics.
ISIS-ANGPTL3 is an antisense drug we designed to reduce angiopoietin-like 3 protein, or ANGPTL3, an independent risk factor for cardiovascular disease. ANGPTL3 is produced in the liver and regulates lipid, glucose and energy metabolism.
ISIS-APOCIII is an antisense drug we designed to reduce apolipoprotein C-III, or apoC-III, protein production and lower triglycerides. ApoC-III regulates triglyceride metabolism in the blood and is an independent cardiovascular risk factor. Humans who do not produce apoC-III have lower levels of triglycerides and lower instances of cardiovascular disease.
Indomethacin is a non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.Antiinflammatory effects of Indomethacin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.The following symptoms may be observed following overdosage: nausea, vomiting, intense headache, dizziness, mental confusion, disorientation, or lethargy. There have been reports of paresthesias, numbness, and convulsions.
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