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MHY1485 analytical pure 0.996

MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.

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MK-4827 analytical pure 0.999

MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively.

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MK-8617 analytical pure 0.996

MK-8617 is a potent, selective, orally bioavailabl pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.

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OTX-015 analytical pure 0.994

OTX-015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays.

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PD0325901 analytical pure 98%

PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.

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PD98059 analytical pure 0.998

PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2.

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PKI-587 analytical pure 0.987

PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM, 5.4 nM and 1.6 nM for PI3Kα, PI3Kγ and mTOR, respectively.

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PLX4720 analytical pure 0.998

PLX 4720 is a potent and selective inhibitor of B-RafV600E (IC50=13 nM) and c-Raf-1Y340D/Y341D (IC50=6.7 nM), whth a 10-fold selectivity for B-RafV600E than wild-type B-Raf.

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PS-1145 analytical pure 0.997

PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM.

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Rapamycin analytical pure 98%

Rapamycin is a specific mTOR inhibitor with IC50 of ~0.1 nM.

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