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Naloxonazine is an irreversible mu opioid antagonist.


Neticonazole is an imidazole antifungal for the treatment of fungal skin infections.


Nifuroxazide is an oral nitrofuran antibiotic, patented since 1966 and used to treat colitis and diarrhea in humans and non-humans.

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Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. It is used for the treatment of infectious diarrhea caused by Cryptosporidium parvum and Giardia lamblia in patients 1 year of age and older. It is currently in Phase II clinical trials for the treatment of hepatitis C, in combination with peginterferon alfa-2a and ribavirin.

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Nitrobenzene is an organic compound. It is produced on a large scale as a precursor to aniline. Although occasionally used as a flavoring or perfume additive, nitrobenzene is highly toxic in large quantities. In the laboratory, it is occasionally used as a solvent, especially for electrophilic reagents. It is also used in shoe and floor polishes, leather dressings, paint solvents, and other materials to mask unpleasant odors. A significant merchant market for nitrobenzene is its use in the production of the analgesic paracetamol. It is also used in Kerr cells, as it has an unusually large Kerr constant.

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Nitromethane is an organic compound. It is a slightly viscous, highly polar liquid commonly used as a solvent in a variety of industrial applications such as in extractions, as a reaction medium, and as a cleaning solvent. As an intermediate in organic synthesis, it is used widely in the manufacture of pharmaceuticals, pesticides, fibers, and coatings. It is also used as a racing fuel in Top Fuel drag racing, and as an important component in the fuel for the miniature internal combustion engines used, for example, in radio-controlled models.

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Norclozapine is a major active metabolite of the atypical antipsychotic drug clozapine. Interestingly, unlike clozapine, it possesses intrinsic activity at the D2/D3 receptors, and acts as a weak partial agonist at these sites similarly to aripiprazole and bifeprunox. It has also been shown to act as a potent and efficacious agonist at the M1 and δ-opioid receptors, unlike clozapine as well. Therefore, norclozapine is considered a delta-opioid agonist. It was hypothesized that on account of these unique actions, norclozapine might underlie the clinical superiority of clozapine over other antipsychotics. However, clinical trials found norclozapine itself ineffective in the treatment of schizophrenia. This may be because it possesses relatively low D2/D3 occupancy compared to 5-HT2.

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Obinutuzumab is a humanized anti-CD20 monoclonal antibody.Obinutuzumab is used in combination with chlorambucil as a first-line treatment for chronic lymphocytic leukemia.Its progression-free survival is better than rituximab in the same combinationbut its overall survival rate is not better.It is also used in combination with bendamustine followed by obinutuzumab monotherapy for the treatment of patients with follicular lymphoma as a second line treatment to a regimen containing rituximab.Obinutuzumab binds to CD20 on B cells and causes these cells to be destroyed by engaging the adaptive immune system, directly activating intracellular apoptosis pathways, and activating the complement system.

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Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of Fascioliasis in ruminants mainly domestic animals like cattle, sheep and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes.

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Paliperidone is the primary active metabolite of the older antipsychotic risperidone.Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone, as with other drugs having efficacy in schizophrenia.It has been proposed that the drug's therapeutic activity in schizophrenia ismediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis

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