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Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is used as an adjunct to dietary therapy to treat primary hypercholesterolemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia and it also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. It is also used to lower total cholesterol, low density lipoprotein-cholesterol (LDL-C), apolipoprotein B (apoB), non-high density lipoprotein-cholesterol (non-HDL-C), and trigleride (TG) plasma concentrations while increasing HDL-C concentrations.
Salicylamide is a non-prescription drug with analgesic and antipyretic properties. Its medicinal uses are similar to those of aspirin. It is used in combination with both aspirin and caffeine in the over-the-counter pain remedies such as BC Powder and PainAid.
Sazetidine A is a drug which acts as a subtype selective partial agonist at α4β2 neural nicotinic acetylcholine receptors, acting as an agonist at (α4)2(β2)3 pentamers, but as an antagonist at (α4)3(β2)2 pentamers. It has potent analgesic effects in animal studies comparable to those of epibatidine, but with less toxicity, and also has antidepressant action.
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Serrapeptase is an enzyme that is produced in the intestines of silk worms to break down cocoon walls.Serrapeptase has been used to treat chronic sinusitis, carpal tunnel syndrome, sprains and torn ligaments.Serrapeptase can play an important role in arterial plaque (hardening of the arteries) prevention and removal.
Sipon LAT 30 is suited for use as a basic surfactant in cosmetic cleansing preparations such as shampoos, shower gels and foam baths.
Stepholidine is a naturally-occurring chemical compound found in the herb Stephania intermedia. It is a dual D2 receptor antagonist and D1 receptor agonist, and has shown antipsychotic activity in animal studies.
Streptavidin is a 60 kDa protein purified from the bacterium Streptomyces avidinii. Streptavidin homo-tetramers have an extraordinarily high affinity for biotin (also known as vitamin B7). The crystal structure of streptavidin with biotin bound was first solved in 1989 by Hendrickson et al. Streptavidin is used extensively in molecular biology and bionanotechnology due to the streptavidin-biotin complex's resistance to organic solvents, denaturants (e.g. guanidinium chloride), detergents (e.g. SDS, Triton), proteolytic enzymes, and extremes of temperature and pH. Streptavidin is widely used in Western blotting and immunoassays conjugated to some reporter molecule, such as horseradish peroxidase. It has also been used in the developing field of Nanobiotechnology.
Sulfadiazine is an antibiotic.It is used together with pyrimethamine, it is the treatment of choice for toxoplasmosis. Sulfadiazine is a second line treatment for otitis media, prevention of rheumatic fever, chancroid, chlamydia and infections by Haemophilus influenzae.It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.Sulfadiazine is available as a generic medication.It eliminates bacteria that cause infections by stopping the production of folate inside the bacterial cell, and is commonly used to treat urinary tract infections, and burns. Sulfadiazine works by inhibiting the enzyme dihydropteroate synthetase. In combination with pyrimethamine (a dihydrofolate reductase inhibitor), sulfadiazine is used to treat active toxoplasmosis.
Tamibarotene is orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. It is a specific agonist for retinoic acid receptor alpha/beta.
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