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Sulfadiazine

Sulfadiazine is an antibiotic.It is used together with pyrimethamine, it is the treatment of choice for toxoplasmosis. Sulfadiazine is a second line treatment for otitis media, prevention of rheumatic fever, chancroid, chlamydia and infections by Haemophilus influenzae.It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.Sulfadiazine is available as a generic medication.It eliminates bacteria that cause infections by stopping the production of folate inside the bacterial cell, and is commonly used to treat urinary tract infections, and burns. Sulfadiazine works by inhibiting the enzyme dihydropteroate synthetase. In combination with pyrimethamine (a dihydrofolate reductase inhibitor), sulfadiazine is used to treat active toxoplasmosis.

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Tamibarotene

Tamibarotene is orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. It is a specific agonist for retinoic acid receptor alpha/beta.

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Thioperamide

Thioperamide is a potent and selective histamine H3 antagonist that is capable of crossing the blood-brain barrier.

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Trifluridine

Trifluridine is an antiviral derivative of thymidine used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus.Trifluridine interferes with DNA synthesis in cultured mammalian cells. Trifluridine presumably stops replication of herpes viral DNA in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. Trifluridine targets HSV and VSV thymidine kinase.

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Trimegestone

Trimegestone is a steroidal progestin of the 19-norprogesterone group related to promegestone. Trimegestone has very high affinity for the progesterone receptor, only weak affinity for the mineralocorticoid receptor, and little or no affinity for other steroid hormone receptors. It is used as a hormonal contraceptive and in hormonal replacement therapy for postmenopausal symptoms.

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Trimethoprim

Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the intermediate Thymidine monophosphate (dTMP), precursor of DNA metabolite Thymidine triphosphate. Trimethoprim used as monotherapy, is indicated for the prophylaxis and treatment of urinary tract infections.

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Trimipramine

Trimipramine is a tricyclic antidepressant. It has antidepressant, anxiolytic, antipsychotic, sedative, and analgesic effects. Trimipramine is chemically similar to other TCA antidepressants such as imipramine as well as the antipsychotic levomepromazine. Trimipramine is synthesized by treatment of 10,11,Dihydro-5H-dibenz[b,f]azepine and with 3-N,N-Dimethylamino-2-methylpropylchloride in a nucleophilic substitution in present of Sodium amide.

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Troglitazone

Troglitazone is an anti-diabetic and antiinflammatory drug, and a member of the drug class of the thiazolidinediones. Like the other thiazolidinediones it works by activating peroxisome proliferator-activated receptors.

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Valacyclovir

Valaciclovir (INN) or valacyclovir (USAN) is an antiviral drug used in the management of herpes simplex and herpes zoster (shingles). It is a prodrug, being converted in vivo to aciclovir. It is marketed by GlaxoSmithKline under the trade name Valtrex or Zelitrex.Valaciclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competitive inhibition of viral DNA polymerase, and by incorporation into and termination of the growing viral DNA chain.Adverse effects of overexposure might include headache and nausea.

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Verbascoside

Verbascoside is a phenylethanoid and a caffeic acid sugar ester. It has an antimicrobial activity, notably against Staphylococcus aureus. It can also have anti-inflammatory properties. It shows a genotoxicity on human lymphocytes with an involvement of PARP-1 and p53 proteins. It is a protein kinase C inhibitor.

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