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Ro 3306 analytical pure 0.997

Ro 3306 is a potent and selective inhibitor of CDK1 with Ki value of 35 nM for CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and > 50-fold relative to CDK4/cyclin D.

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S3I-201 analytical pure 0.993

S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5.

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SB-216763 analytical pure 98%

SB-216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM) and competes with ATP.

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SNS-032 analytical pure 0.992

SNS-032 is a potent inhibitor of cyclin-dependent kinases (CDKs)9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).

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Stattic analytical pure 0.999

Stattic, a nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1.

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TAK-285 analytical pure 0.997

TAK-285 is a dual HER2 and EGFR (HER1) inhibitor with IC50 of 17 nM and 23 nM, > 10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.

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TP-3654 analytical pure 0.997

TP-3654 is a selective Pim kinase inhibitor with Ki values of 5nM, 239nM and 42nM for Pim-1, Pim-2 and Pim-3, respectively, as well as with an average EC50 of 67nM for cellular PIM-1 inhibition in the PIM-1/BAD overexpression system and with moderate potency to FLT3.

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UNC0224 analytical pure 0.982

UNC0224 is a selective inhibitor of G9a with IC50 of 15 nM.

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UNC1999 analytical pure 0.999

UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM, respectively.

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(+)-JQ-1 analytical pure 0.999

(+)-JQ-1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family.

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