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Amitriptyline is a tricyclic antidepressant. It affects chemicals in the brain that may become unbalanced. Amitriptyline is used to treat symptoms of depression. Amitriptyline may also be used for purposes not listed in this medication guide.It is TGA-labelled for migraine prophylaxis, as it is also is in cases of neuropathic pain disorders, fibromyalgia,and nocturnal enuresis.Amitriptyline is a popular off-label treatment for irritable bowel syndrome.Amitriptyline acts primarily as a serotonin-norepinephrine reuptake inhibitor, with strong actions on the serotonin transporter and moderate effects on the norepinephrine transporter.Amitriptyline is readily absorbed from the gastrointestinal tract and is extensively metabolised on first-pass through the liver.It is metabolised mostly via CYP2D6, CYP3A4, CYP2C19-mediated N-demethylation into nortriptyline.
Anthraquinone is an aromatic organic compound. This compound is an important member of the quinone family. It is a building block of many dyes and is industrially used in bleaching pulp for papermaking. A large industrial application of anthraquinones is for the production of hydrogen peroxide. Derivatives of 9,10-anthraquinone include many important drugs.
Apraclonidine is a sympathomimetic used in glaucoma therapy. It is an α2-adrenergic agonist. It is indicated for the short-term adjunctive treatment of patients on maximally tolerated medical therapy who require additional reduction. Patients on maximally tolerated medical therapy who are treated with apraclonidine to delay surgery should have frequent followup examinations and treatment should be discontinued if the intraocular pressure rises significantly.
Aspartic acid is an α-amino acid. The carboxylate anion of aspartic acid is known as aspartate. Aspartate is pervasive in biosynthesis. It was first discovered in 1827 by Plisson, synthesized by boiling asparagine with a base.
Asymbescaline is a lesser-known psychedelic drug. It is a homologue of Mescaline. It was first synthesized by Alexander Shulgin. It produces few to no effects.
Azidomorphine is an opiate analogue that is a derivative of morphine, where the 7,8 double bond has been saturated and the 6-hydroxy group has been replaced by an azide group. It binds with high affinity to the mu opioid receptor. It has similar effects to other opioid agonists including analgesia, sedation and respiratory depression. However its addiction liability has been found to be slightly lower than that of morphine in animal studies.
Bacampicillin is an antibiotic in the class of drugs called penicillins. It fights bacteria in the body. Bacampicillin is used to treat many different types of infections, such as tonsillitis, pneumonia, bronchitis, urinary tract infections, gonorrhea, and infections of the skin. Bacampicillin may also be used for purposes other than those listed in this medication guide.
Barium Iodide compounds are used in internal medicine.
Benzbromarone is a uricosuric agent used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects. It is structurally related to the antiarrhythmic amiodarone. It is highly effective and well-tolerated, and clinical trials as early as 1981 and as recently as April 2008 have suggested it is superior to both allopurinol and probenecid, another uricosuric drug.
Benzobarbital is a barbiturate derivative. It has anticonvulsant effects and has been used for the treatment of epilepsy. It has similar liver enzyme inducing effects to the closely related drug phenobarbital, which may be exploited in some clinical applications.
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