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Novata 299 PH

Novata 299 PH are white to slightly yellowish, brittle pellets which are used for the production of suppositories. On account of the higher hydroxyl value range, active agents can be integrated which react with hydroxyl groups.


Oxymetazoline was developed from xylometazoline at E.Merck Darmstadt by Fruhstorfer in 1961. It is used to treat epistaxis and eye redness due to minor irritation.

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Oxymorphazone is an opioid analgesic drug related to oxymorphone. It is a potent and long acting μ-opioid agonist which binds irreversibly to the receptor, forming a covalent bond which prevents it from detaching once bound. This gives it an unusual pharmacological profile, and while oxymorphazone is only around half the potency of oxymorphone, with higher doses the analgesic effect becomes extremely long lasting, with a duration of up to 48 hours. However with repeated doses, tolerance to the effects develops rapidly, as chronically activated opioid receptors are rapidly internalised by β-arrestins, in a similar manner as occurs with non-covalent binding by agonists with extremely high binding affinity such as lofentanil.


Pentamorphone is a semi-synthetic opiate derivative related to compounds such as morphine, hydromorphone and oxymorphone. Developed in 1984, it is a potent opioid analgesic several times stronger than fentanyl, and with a similarly fast onset of effects and short duration of action. It was found to produce relatively little respiratory depression compared to other potent opioid agonists, but its analgesic effects were somewhat disappointing in human trials, and while pentamorphone had some slight advantages over fentanyl these were not sufficient to warrant its introduction into clinical use.


Pentobarbital is a short-acting barbiturate that was first synthesized in 1928. Pentobarbital's FDA-approved human uses include treatment of seizures and preoperative (and other) sedation; it is also approved as a short-term hypnotic.

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Phencyclidine is also known as angel dust is a recreational, dissociative drug formerly used as an anesthetic agent, exhibiting hallucinogenic and neurotoxic effects.PCP works primarily as an NMDA receptor antagonist.

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Phenmetrazine is a stimulant drug of the morpholine chemical class that was previously used as an appetite suppressant. It was initially replaced by its analogue phendimetrazine which functions as a prodrug to phenmetrazine, but now it is rarely prescribed, due to concerns of abuse and addiction.

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Phenobarbital is a long-acting barbiturate and the most widely used anticonvulsant worldwide and the oldest still commonly used. It also has sedative and hypnotic properties, but as with other barbiturates, it has been superseded by the benzodiazepines for these indications. It is no less effective at seizure control than more modern drugs such as phenytoin and carbamazepine. It is, however, significantly less well tolerated. Phenobarbital is the first-line choice for the treatment of neonatal seizures. Phenobarbital is sometimes indicated for alcohol and benzodiazepine detoxification for its sedative and anticonvulsant properties. Phenobarbital properties can effectively reduce tremors and seizures associated with abrupt withdrawal from benzodiazepines. Phenobarbital is a cytochrome P450 inducer, and is used to reduce the toxicity of some drugs. Phenobarbital is occasionally prescribed in low doses to aid in the conjugation of bilirubin in people with Crigler-Najjar syndrome (Type II), or in patients suffering from Gilbert syndrome.

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Phenprocoumon is an anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders. It inhibits vitamin K reductase.

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