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KU-0063794 analytical pure 98%

KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2 respectively) with no effect on PI3Ks.

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KU-55933 analytical pure 0.998

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

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LY294002 analytical pure 0.999

LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM in cell-free assays.

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LY364947 analytical pure 0.996

LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, exhibits 7-fold selectivity over TGFβR-II.

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NAV-2729 analytical pure 0.987

NAV-2729 is a selective ARF6 inhibitor with IC50 of 1 μM.

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Olaparib analytical pure 0.999

Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.

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PD166866 analytical pure 0.994

PD 166866 is a selective FGFR tyrosine kinase inhibitor with an IC50 of 52.4 nM.

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PD173074 analytical pure 0.993

PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.

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Perifosine analytical pure 98%

Perifosine is an Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt.

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RMC-4550 analytical pure 0.999

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 enzyme with IC50 value of 0.58 nM, without activity against the SHP2 catalytic domain up to a concentration of 10 µM.

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