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Methylphenidate is used for the treatment of attention deficit hyperactivity disorder.
Minodronic acid is a third-generation bisphosphonate drug. It is approved for use in Japan for the treatment of osteoporosis.Its mechanism of action involves inhibition of farnesyl pyrophosphate synthase activity.
N-Methylglycine is an intermediate and byproduct in glycine synthesis and degradation. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other applications.It is present in foods such as egg yolks, turkey, ham, vegetables, legumes, etc.
Naproxen Sodium belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It reduces swelling, inflammation and pain, and is used for the relief of mild to moderately severe pain accompanied by inflammation. Naproxen Sodium is used to help relieve pain due to muscle injury, (e.g., bone, muscle, tendon, cartilage, ligament), dental extraction, menstrual cramps, and cramping after childbirth. Naproxen Sodium works by stopping the production of prostaglandins, which cause pain and swelling.
Neosalvarsan is a synthetic chemotherapeutic that is an organoarsenic compound. Both salvarsan and neosalvarsan were developed in the laboratory of Paul Ehrlich in Frankfurt, Germany. Their discoveries were the result of the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications. This scheme is the basis for most modern pharmaceutical research. Both salvarsan and neosalvarsan are prodrugs — that is, they are metabolised into the active drug in the body.
Nucleant Tablets are used for grain refining of aluminium and its alloys. Usually, aluminum and its alloys solidify with coarse columnar and equiaxed crystals and tends to cluster. Such a coarse grain structure poses problems like poor feeding characteristics, lower tensile strength, low wear resistance, cracking during metal working and poor response to the surface treatment processes. Therefore, we require Nucleants to overcome these problems by producing fine equiaxed grains.
Toluidines are used in the production of dyes. They are a component of accelerators for cyanoacrylate glues. They are toxic and are suspected human carcinogens. o-Tolidine, used as a presumptive test for blood in forensic science, is two o-toluidine molecules linked together.
Oxyphenbutazone is a metabolite of phenylbutazone. It is a non-steroidal anti-inflammatory drug.
Palbociclib HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib HCl selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation;inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. It is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50 = 0.011μmol/L) and Cdk6 (IC50 = 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases.
Pamidronic acid is used to prevent osteoporosis. It is marketed by Novartis under the brand name Aredia. It is used to prevent bone loss, and in certain cancers with high propensity to bone, such as multiple myeloma. In multiple myeloma, it is usually administered as an intravenous infusion, lasting about 3 hours. The therapy is repeated monthly, and lasts for the life of the patient. Due to its ability to sequester calcium in bone, it is also used to treat high calcium levels. It is also used as an experimental treatment of the bone disorder known as Osteogenesis Imperfecta, or brittle bones.
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