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O-Demethyltramadol

O-Desmethyltramadol is an opioid analgesic and the main active metabolite of tramadol. It is the most important metabolite of tramadol produced in the liver after tramadol is consumed. This metabolite is considerably more potent as a μ opioid agonist than the parent compound.

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O-Desmethylvenlafaxine

Desvenlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. It is a synthetic form of the major active metabolite of venlafaxine. It is being targeted as the first non-hormonal based treatment for menopause.

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OSU-03012

OSU-03012 is an orally available, targeted anti-cancer agent that has been shown in pre-clinical studies to inhibit PDK-1, a protein in the PI3K/Akt pathway that is involved in the growth and proliferation of cells, including cancer cells. It may also cause cell death through the induction of stress in the endoplasmic reticulum.

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Obinutuzumab

Obinutuzumab is a humanized anti-CD20 monoclonal antibody.Obinutuzumab is used in combination with chlorambucil as a first-line treatment for chronic lymphocytic leukemia.Its progression-free survival is better than rituximab in the same combinationbut its overall survival rate is not better.It is also used in combination with bendamustine followed by obinutuzumab monotherapy for the treatment of patients with follicular lymphoma as a second line treatment to a regimen containing rituximab.Obinutuzumab binds to CD20 on B cells and causes these cells to be destroyed by engaging the adaptive immune system, directly activating intracellular apoptosis pathways, and activating the complement system.

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Ocatanedinitrile

Ocatanedinitrile is used as pharmaceutical intermediate.

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Octopamine

Octopamine is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems. It was first discovered by Italian scientist Vittorio Erspamer in 1948 in the salivary glands of the octopus and has since been found to act as neurotransmitter, neurohormone and neuromodulator in invertebrates. It is widely used in energy-demanding behaviors by all insects, crustaceans and spiders. In vertebrates, octopamine replaces norepinephrine in sympathetic neurons with chronic use of monoamine oxidase inhibitors. It may be responsible for the common side effect of orthostatic hypotension with these agents, though there is also evidence that it is actually mediated by increased levels of N-acetylserotonin.

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Octreotide Acetate

Octreotide Acetate is a very potent inhibitor of many hormones such as growth hormone, glucagon and insulin. Octreotide acetate Peptide mimics the effects of natural hormone somatostatin. Octreotide Acetate is the water-soluble acetate salt of a cyclic octapeptide.It is used in the treatment of diarrhea associated with carcinoid tumors, and profuse watery diarrhea associated with vasoactive intestinal peptide tumors (VIPoma). Octreotide Acetate is also a treatment for acromegaly.

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Olanzapine

Olanzapine is an atypical antipsychotic.Olanzapine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Olanzapine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors.Symptoms of an overdose include tachycardia, agitation, dysarthria, decreased consciousness and coma. Death has been reported after an acute overdose of 0.45g, but also survival after an acute overdose of 1500g

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Oleic Acid

Oleic acid in chemical terms is monounsaturated omega-9 fatty acid because of the single double bond between the carbons. It has the formula of C18H34O2 and is pale yellow or brownish yellow oily liquid with lard-like odor. Oleic acid is the emollient in cosmetics, an emulsifying agent in soaps, the excipient in pharmaceuticals and solubilizer in aerosol products.

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