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RMC-4550 analytical pure 0.999

RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 enzyme with IC50 value of 0.58 nM, without activity against the SHP2 catalytic domain up to a concentration of 10 µM.

SB-431542 analytical pure 0.99

SB-431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold selective for ALK5 than p38 MAPK and other kinases.

SGI-1776 analytical pure 0.998

SGI-1776 free base is an ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin.

SLV-2436 analytical pure 0.994

SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8  nM and 5.4 nM, respectively.

SNX-2112 analytical pure 0.999

SNX-2112 is a potent synthetic heat shock protein 90 (HSP90) inhibitor with an IC50 of 0.92 μM for K562 cells.

Sorafenib analytical pure 0.99

Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM in cell-free assays, respectively.

Tariquidar analytical pure 98%

Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM, reverses drug resistance in MDR cell Lines.

Z-IETD-FMK analytical pure 98%

Z-IETD-FMK is a specific Caspase-8 inhibitor.

A-1210477 analytical pure 0.999

A-1210477 is a potent and selective inhibitor of MCL-1, and weakly binds to BCL-2 and BCL-XL, with Ki of 0.45 nM, 132 nM and > 660 nM, respectively.

AS-1517499 analytical pure 0.98

AS-1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.

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