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PEG 400, PEG 600, PEG 4000, PEG 6000

Pharma excipent for liquid orals and ointments. Anti freeze for brake fluids.

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PIK-75 LAB GRADE 97%

PIK-75 was developed as part of a PI 3-kinase drug discovery program. PIK75 attenuates insulin stimulation of Akt/PKB in a range of cell types at 100 nM. The compound has been reported to block growth of a range of cell lines with an IC50 value in the region of 50 nM. In vivo studies have shown that PIK-75, administered at 50 mg/kg, inhibited the growth of HeLa cell xenografts in mice models. http://www.bocsci.com/pik-75-cas-372196-67-3-item-84-91237.html

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PLX-4720

PLX4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.

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PNU-22394

PNU-22394 is a drug which acts as an agonist at serotonin 5-HT2 receptors, with strongest binding affinity for 5-HT2A and 5-HT2C and slightly weaker at 5-HT2B, although it is only a full agonist at 5-HT2C, but partial agonist at 5-HT2A and 5-HT2B. It has anorectic effects in both animal studies and human trials, although it has never been developed for medical use.

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Pagoclone

Pagoclone is an anxiolytic drug from the cyclopyrrolone family, related to better-known drugs such as the sleeping medication zopiclone. It is one of a relatively recently developed class of medicines known as the nonbenzodiazepines, which have similar effects to the older benzodiazepine group, but with quite different chemical structures. It was originally developed as an anti-anxiety drug, but never commercialised. It is a partial agonist acting at GABAA receptors in the brain. In contrast to zopiclone, pagoclone produces anxiolytic effects with little or no sedative or amnestic actions at low doses. This is because pagoclone is a subtype-selective drug which binds primarily to the α2 and α3 subtypes of the GABAA receptor which are responsible for the anti-anxiety effects of these kind of drugs, but has relatively little efficacy at the α1 subtype which produces the sedative and memory loss effects.

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Palbociclib HCl

Palbociclib HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib HCl selectively inhibits cyclin-dependent kinases (particularly Cdk4/cyclin D1 kinase), which may inhibit retinoblastoma (Rb) protein phosphorylation;inhibition of Rb phosphorylation prevents Rb-positive tumor cells from entering the S phase of the cell cycle (arrest in the G1 phase), resulting in suppression of DNA replication and decreased tumor cell proliferation. It is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) (IC50 = 0.011μmol/L) and Cdk6 (IC50 = 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases.

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Paliperidone

Paliperidone is the primary active metabolite of the older antipsychotic risperidone.Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone, as with other drugs having efficacy in schizophrenia.It has been proposed that the drug's therapeutic activity in schizophrenia ismediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.The possibility of obtundation, seizures, or dystonic reaction of the head and neck following overdose may create a risk of aspiration with induced emesis

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Palladium Chloride Industrial Grade 99.9%

Palladium chloride is brown crystalline powder, which tend to deliquesce. It is soluble in water, hydrochloric acid, ethyl alcohol, acetone and hydrobromic acid. It is stable in air. Palladium metal or sponge palladium is the raw material.

Palladium Chloride

CAS No.:7647-10-1 EINECS No.:231-596-2 Molecular Formula:PdCl2.2H2O Molecular Weight:177.33
Melting Point:680℃ Density:4.0 Purity:99.9% Pd≥59.5%

Applications

Palladous chloride is for preparing special catalyst and molecular sieve. It is for formulating surface active agent in cladding material of non-conductor material. It is also for making gas sensitive element.

Palladium(II) chloride is a kind of analytical reagent too. It can test palladium, mercurythallium and iodine. Palladium chloride test paper can examine carbon monoxide and cobalt.

Palladium(+2) chloride applies to synthesize semiconductor polymer containing metals. It applies to acetaldehyde’s catalyst by ethylene method and other palladium catalysts.

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Pamidronate Disodium

Pamidronate Disodium is indicated, in conjunction with standard antineoplastic therapy, for the treatment of osteolytic bone metastases of breast cancer and osteolytic lesions of multiple myeloma. It is a bisphosphonate antiresorptive agent and a bone resorption inhibitor.

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Pamidronic acid

Pamidronic acid is used to prevent osteoporosis. It is marketed by Novartis under the brand name Aredia. It is used to prevent bone loss, and in certain cancers with high propensity to bone, such as multiple myeloma. In multiple myeloma, it is usually administered as an intravenous infusion, lasting about 3 hours. The therapy is repeated monthly, and lasts for the life of the patient. Due to its ability to sequester calcium in bone, it is also used to treat high calcium levels. It is also used as an experimental treatment of the bone disorder known as Osteogenesis Imperfecta, or brittle bones.

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