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Pharmaceutical Raw Materials Vinblastine Sulfate For Antineoplastic 143-67-9

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Pharmaceutical Raw Materials Vinblastine Sulfate For Antineoplastic 143-67-9
Vinblastine Sulfate Basic Info.:
Product Name: Vinblastine Sulfate
Synonyms: 29060LE;EXAL;NSC49842;Rozevinsulfate;Velban;Velbe;Vincaleukoblastine,Sulfate(1:1)(Salt);Vinblastine Sulfate Salt;
CAS: 143-67-9
MF: C46H60N4O13S
MW: 909.05
EINECS: 205-606-0
Purity: 99.5%
Melting point: 267 °C (dec.)(lit.)
Alpha: -21.7 º (c=2, CH3OH 21 ºC)
Storage temp.: 2-8°C
Solubility: H2O: 10 mg/mL
Water Solubility: >=1 g/100 mL at 24.5 ºC
Standard: USP /EP /BP 
Appearance: White to slightly yellow crystalline powder.
Usage: Antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
Vinblastine Sulfate Introduction:
Mainly used for the treatment of solid tumor. For malignant lymphoma, testicular neoplasm and choriocarcinoma curative effect is better. For lung, breast, ovarian, skin cancer, renal mother cell tumor and monocytes leukaemia also have certain curative effect.
Pharmacology: Vinblastine Vinca plants for the oleander extract has anti-cancer activity of an alkaloid. Major inhibition of tubulin polymerization, preventing the formation of spindle microtubules, so stop in MID-mitosis. Role in the cell membrane can also interfere with membrane transport of amino acids, protein synthesis was inhibited, also inhibited RNA synthesis.
Vinblastine Sulfate Function:
1. Mainly used in the treatment of Hodgkin's disease, lymphatic reticulum cell sarcoma, chorionic carcinoma, testicular tumor. Is also effective for other malignant lymphoma.
2. For acute leukemia, mononuclear cell leukemia, lung cancer, breast cancer, ovarian cancer, kidney tumor, oral cancer, malignant melanoma, skin cancer have certain curative effect.
3. Treatment of idiopathic thrombocytopenic purpura.
4. Treatment of rheumatoid arthritis.

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