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Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids.
Polysorbate 20 is a nonionic surfactant and emulsifier derived from polyoxyethylene derivative of sorbitan monolaurate which comes from fruit and berries.It is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide the spreading feeling of the other ingredients like SD alcohol and mint flavor,used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.Polysorbate 20 is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.It is also used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
Polysorbate 20 PH is a clear , light yellow to brownish-yellowish liquid with a faint odour.It is used as a non-ionic, hydrophilic emulsifier and/or solubilzer for pharmaceutical preparations (creams and ointments).
Polysorbate 60 is used in detergent, cosmetic and pharmaceuticals. it is also used as an emulsifier for plastic & polymers, personal care and industrial applications.
Polysorbate 80 is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan and oleic acid. It is used as an emulsifier in foods, particularly in ice cream. Adding this substance prevents milk proteins from completely coating the fat droplets. It is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the manufacture of the popular anti-arrhythmic amiodarone. It is also used as an excipient in some European and Canadian influenza vaccines. It is used as a test to identify the phenotype of a strain or isolate.
Polysorbate 85 is used as an emulsifier in combination with a variety of other hydrophobic emulsifiers to cover a wide range of oil in water, and water in oil emulsion systems. Individually, it is an excellent solubilizer of vegetable oils and fragrances, a wetting agent, viscosity modifier, stabilizer and dispersing agent. Useful for oil-in-water emulsions, and to make anhydrous ointments water soluble or washable.
Polyvinylpyrrolidone is a water-soluble polymer made from the monomer N-vinylpyrrolidone. It was used as a blood plasma expander. It is used as a binder in many pharmaceutical tablets. It is also used as additive for batteries, ceramics, fiberglass, inks, inkjet paper and in the chemical-mechanical planarization process, use in aqueous metal quenching, for production of membranes, such as dialysis and water purification filters.
Ponatinib is an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities.Ponatinib was approved by the US FDA on December 14, 2012, for patients with resistant or intolerant CML and Ph+ ALL, based on results of the PACE phase II trial reported days earlier at the annual ASH meeting.Ponatinib was designed using ARIAD’s computational and structure-based drug design platform to inhibit the enzymatic activity of BCR-ABL with very high potency and broad specificity. Ponatinib was intended to target not only native BCR-ABL, but also its isoforms that carry mutations that confer resistance to treatment with existing tyrosine kinase inhibitors, including especially the T315I mutation for which no effective therapy exists.
Posaconazole is a triazole antifungal drug. It is used to treat invasive infections by Candida species, Mucor, and Aspergillus species in severely immunocompromised patients. There is also limited clinical evidence for its utility in treatment of invasive disease caused by Fusarium species (fusariosis).
Potassium acetate is the potassium salt of acetic acid. It can be used as a deicer instead of chloride salts such as calcium chloride or magnesium chloride. In medicine, potassium acetate is used as part of replacement protocols in the treatment of diabetic ketoacidosis because of its ability to break down into bicarbonate and help neutralize the acidotic state. It is used as a food additive as a preservative and acidity regulator.
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