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I-BET-762 analytical pure 0.993

I-BET 762 is an inhibitor for BET proteins with IC50 of ~35 nM.

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Ibrutinib analytical pure 0.999

Ibrutinib is a potent Btk inhibitor with IC50 value of 0.5nM, modestly potent to Blk (IC50=0.5nM), Bmx (IC50=0.8nM), CSK (IC50=2.3nM), FGR (IC50=2.3nM), BRK (IC50=3.3nM), HCK (IC50=3.7nM).

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Icatibant analytical pure 0.985

Icatibant is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

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Indoximod analytical pure 0.995

Indoximod is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki of 19 μM.

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LY2090314 analytical pure 0.996

LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.

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LY2109761 analytical pure 0.985

LY2109761 is a selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively and is shown to negatively affect the phosphorylation of Smad2.

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LY2603618 analytical pure 0.998

LY2603618 is a highly selective Chk1 inhibitor with potential anti-tumor activity. In a cell-free assay, it shows an IC50 of 7 nM, approximately 100-fold more potent against Chk1 than against any of the other protein kinases evaluated.

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LY2874455 analytical pure 0.997

LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM.

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LY3000328 analytical pure 0.991

LY 3000328 is a highly selective and potent Cathepsin S inhibitor with IC50 of 7.7±5.85 nM and 1.67±1.17 nM for hCat S and mCat S respectively, can be used in treatment for abdominal aortic aneurysm.

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LY3009120 analytical pure 0.994

LY3009120 is a small molecule that has been shown to be a pan-RAF inhibitor of all isoforms, inhibiting BRAFV600E, BRAFWT and CRAFWT with IC50 values of 5.8, 9.1 and 15 nM and blocking proliferation in both BRAF and RAS mutant cells.

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