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Entinostat analytical pure 0.996

Entinostat strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM.

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Everolimus analytical pure 0.986

Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.

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Fevipiprant analytical pure 0.99

Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.

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GSK2126458 analytical pure 0.999

GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively.

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GSK2141795 analytical pure 0.992

GSK2141795 is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3,

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GSK2256098 analytical pure 0.996

GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.

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GSK2606414 analytical pure 0.995

GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM.

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Ganetespib analytical pure 0.998

Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.

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Irbinitinib analytical pure 0.99

Irbinitinib is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold selective for HER2 versus EGFR.

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Lenvatinib analytical pure 0.993

Lenvatinib is a multi-target inhibitor, mostly for VEGFR2 (KDR)/VEGFR3 (Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold selective for VEGFR2/3 against FGFR1, PDGFRα/β.

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