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Defactinib analytical pure 0.999

Defactinib is a potent FAK phosphorylation inhibitor and overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway.

Entinostat analytical pure 0.996

Entinostat strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM.

Everolimus analytical pure 0.986

Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.

Fevipiprant analytical pure 0.99

Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood.

GSK2126458 analytical pure 0.999

GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively.

GSK2141795 analytical pure 0.992

GSK2141795 is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3,

GSK2256098 analytical pure 0.996

GSK2256098, is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.

GSK2606414 analytical pure 0.995

GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM.

Ganetespib analytical pure 0.998

Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.

Irbinitinib analytical pure 0.99

Irbinitinib is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold selective for HER2 versus EGFR.

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