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Poziotinib analytical pure 0.998

Poziotinib is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.

Romidepsin analytical pure 0.999

Romidepsin is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.

Salubrinal analytical pure 0.999

Salubrinal is a selective inhibitor of eukaryotic translation initiation factor 2 subunit α (eIF2α) dephosphorylation.

Tat-NR2B9c analytical pure 0.982

Tat-NR2B9c is a PSD95 inhibitor with EC50 of 7 nM, also inhibit p38.

Tideglusib analytical pure 0.996

Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.

Tozasertib analytical pure 0.999

Tozasertib is the inhibitor of Aurora-A, -B, -C kinases with Ki values of 0.6, 18, 4.6 nM respectively.

Trametinib analytical pure 0.999

Trametinib is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.

VER-155008 analytical pure 0.998

VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively, > 100-fold selectivity over HSP90.

Vadadustat analytical pure 0.998

Vadadustat is used for treatment of anemia and chronic kidney disease by Leading to stabilization and increased levels of HIFα and improving production of hemoglobin and red blood cells (RBCs) while maintaining normal levels of erythropoietin (EPO).

Vandetanib analytical pure 0.995

Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.

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