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Vorinostat analytical pure 0.999

Vorinostat is an HDAC1/3 inhibitor with IC50 of ~10 nM.

3-Aminopyrazine-2-carboxylic acid

3-Aminopyrazine-2-carboxylic acid is used as Antidiabetic.

Afuresertib analytical pure 0.998

Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively.

BAY 11-7082 analytical pure 0.999

BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. It also inhibits components of the ubiquitin system through inactivating the E2-conjugating enzymes Ubc (ubiquitin conjugating) 13 and UbcH7 and the E3 ligase LUBAC (linear ubiquitin assembly complex).

BAY 11-7085 analytical pure 0.998

BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.

BAY 87-2243 analytical pure 0.995

BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation.

Bardoxolone analytical pure 0.989

Bardoxolone is a nuclear regulator factor (Nrf-2) activator.

CBL0137 HCl analytical pure 0.995

CBL0137 HCl is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.

CX-6258 HCl analytical pure 0.985

CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.

Cabazitaxel analytical pure 0.992

Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel exerts its effects by inhibiting microtubule growth and assembly, processes that are essential for cells to divide and grow.

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