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Osimertinib analytical pure 0.997

Osimertinib is a potent and selective mutated forms EGFR inhibitor (Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).

PF-05089771 analytical pure 0.985

PF-05089771 is a Nav1.7 channel blocker with an IC50 of 8.6 nM.

PF-06840003 analytical pure 0.999

PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor with IC50 of 0.41 μM.

Pentostatin analytical pure 0.999

Pentostatin can inhibit adenosine deaminase irreversibly with Ki of 2.5 pM, as an antineoplastic anti-metabolite used in the treatment of several forms of leukemia.

Pirfenidone analytical pure 0.999

Pirfenidone is an inhibitor for TGF-β production and TGF-β stimulated collagen production, reduces production of TNF-α and IL-1β, and also has anti-fibrotic and anti-inflammatory properties.

Pracinostat analytical pure 0.995

Pracinostat is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6 and has no activity against the class III isoenzyme SIRT I.

Roscovitine analytical pure 0.999

Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6.

Ruxolitinib analytical pure 0.999

Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, > 130-fold selectivity for JAK1/2 versus JAK3.

TCS PIM-1 1 analytical pure 0.965

TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s > 20,000 nM).

U0126 Ethanol analytical pure 98%

U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM.

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