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Sunitinib Malate analytical pure 0.998

Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

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Imatinib Mesylate analytical pure 0.999

Imatinib Mesylate is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

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Treprostinil Sodium analytical pure 97%

Treprostinil sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

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Tyrphostin AG 879 analytical pure 0.994

Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.

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2-Methoxyestradiol analytical pure 0.998

2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.

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Bardoxolone Methyl analytical pure 0.994

Bardoxolone methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. It is also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.

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ISRIB trans-Isomer analytical pure 0.986

The ISRIB trans-Isomer showed effect on inhibition of the ATF4 luciferase reporter in HEK293T cells treated with 2 µg/ml of tunicamycin to induce ER stress with IC50 value of 5nM.

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PF-562271 Besylate analytical pure 0.993

PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.

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Sorafenib Tosylate analytical pure 0.992

Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively. Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro.

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INCB024360 Analogue analytical pure 0.997

INCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM.

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