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2-Methoxyestradiol analytical pure 0.998

2-methoxyestradiol is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.

Bardoxolone Methyl analytical pure 0.994

Bardoxolone methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. It is also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.

ISRIB trans-Isomer analytical pure 0.986

The ISRIB trans-Isomer showed effect on inhibition of the ATF4 luciferase reporter in HEK293T cells treated with 2 µg/ml of tunicamycin to induce ER stress with IC50 value of 5nM.

PF-562271 Besylate analytical pure 0.993

PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs.

Sorafenib Tosylate analytical pure 0.992

Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively. Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro.

INCB024360 Analogue analytical pure 0.997

INCB024360 analogue is a potent, competitive IDO1 (indoleamine-(2,3)-dioxygenase) inhibitor with IC50 of 67 nM.

Ningetinib Tosylate analytical pure 0.994

Ningetinib tosylate is an inhibitor of tyrosine kinase inhibitor (TKI) and the IC50 for c-Met, VEGFR2 and Axl are 6.7 nM, 1.9 nM and <1.0 nM respectively.

Rucaparib Phosphate analytical pure 0.996

Rucaparib phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.

Tetrasodium Ethylene Diamine Tetraacetate

Tetrasodium Ethylene Diamine Tetraacetate is the salt resulting from the neutralization of ethylenediaminetetraacetic acid with four equivalents of sodium hydroxide. It is a chelating agent that sequesters a variety of polyvalent cations such as Calcium and Magnesium.

Gemifloxacin Mesylate analytical pure 0.99

Gemifloxacin mesylate is an oral broad-spectrum quinolone antibacterial agent, used in the treatment of acute bacterial exacerbation of chronic bronchitis, and mild-to-moderate pneumonia.

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