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ATL1103

ATL1103 is an antisense drug that targets the growth hormone receptor, or GHr, a receptor that, when inhibited, reduces the level of circulating insulin-like growth factor-1, or IGF-1, produced in the liver.

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AZD1152-HQPA

AZD1152-HQPA is an active metabolite of Barasertib which is a novel acetanilide-substituted pyrazole-aminoquinazoline prodrug that is converted rapidly to the active drug AZD-1152 hydroxy-QPA (AZD1152-HQPA) in human plasma. AZD1152-HQPA is a specific inhibitor of the enzymatic activity of Aurora kinase, with selectivity for Aurora B (IC50 of 0.37 nM versus 1368 nM for Aurora B and A kinases, respectively); the inhibitor had even less activity against a panel of greater than 50 other serine-threonine and tyrosine kinases including FLT3, JAK2, and Abl.

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AZD3839 LAB GRADE 97%

AZD3839, with the potential to treat Alzheimer’s disease, was reported as a selective BACE1 inhibitor (IC50=4.8μM) for which concentration-dependent lowering of Ab peptides in cellular systems and three pre-clinical species were demonstrated.http://www.bocsci.com/azd3839-cas-1227163-56-5-item-474091.html

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AZD5438

AZD5438 is a potent inhibitor of cyclin-dependent kinase. AZD5438 showed significant antiproliferative activity in human tumor cell lines causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH-terminal domain and blocking cell cycling at G(2)-M, S, and G(1) phases.

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Abacavir

Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. It has been well tolerated: the main side effect is hypersensitivity, which can be severe, and in rare cases, fatal.

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Abacavir Sulfate

Abacavir Sulfate is a synthetic carbocyclic nucleoside analogue with inhibitory activity against HIV-1. It is an important antiretroviral drug which is a guanosin analogue and nucleosidal reverse transcriptase inhibitor. It does not completely eliminate HIV from the body or totally restore the immune system.

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Abafungin

Abafungin is a broad-spectrum antifungal agent with a novel mechanism of action for the treatment of dermatomycoses.

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Abanoquil

Abanoquil is an α1-adrenergic receptor antagonist.

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Abarelix

Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market.The maximum tolerated dose of abarelix has not been determined. The maximum dose used in clinical studies was 150 mg. Abarelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion.There have been no reports of accidental overdose with abarelix.

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Abatacept

Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). It is produced through recombinant DNA technology in mammalian cells.Abatacept is a selective costimulation modulator, shown to inhibit Tcell (T lymphocyte) activation by binding to CD80 and CD86, thereby blocking interaction with CD28. Blockade of this interaction has been shown to inhibit the autoimmune T-Cell activation that has been implcated in the pathogenesis of rheumatoid arthritis.Doses up to 50 mg/kg have been administered without apparent toxic effect.

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