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Uracil is a common and naturally occurring pyrimidine derivative.It is a planar, unsaturated compound that has the ability to absorb light.It was isolated by hydrolysis of yeast nuclein that was found in bovine thymus and spleen, herring sperm, and wheat germ.It is involved in the transmission of hereditary characteristics.Uracil is one of four nitrogenous bases found in the RNA molecule.It is the hydrogen bond acceptor and can form two hydrogen bonds.It can also bind with a ribose sugar to form the ribonucleoside uridine.It can be used for drug delivery and as a pharmaceutical,used to determine microbial contamination of tomatoes.Its derivatives are more often used as antiphotosynthetic herbicides, destroying weeds in cotton, sugar beet, turnips, soya, peas, sunflower crops, vineyards, berry plantations, and orchards.

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VX-702, one of a series of second-generation, is an orally active p38 MAP kinase inhibitors, for the potential treatment of inflammation, rheumatoid arthritis and cardiovascular diseases.

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WOP 40

WOP 40 is a pharmaceutical grade white mineral oil that consists out of a blend of processed base oils manufactured through hydrocracking saturated aliphatic and alicyclic nonpolar hydrocarbons. It is a colourless, transparent oily liquid,Free from fluorescence in daylight, Insoluble in water, slightly soluble, in alcohol and miscible with hydrocarbons. WOP 40 can be used in cosmetic creams, lotions, sustan oils,sunscreens, Pharmaceutical laxatives, topical ointments and in food packaging materials, food grade lubricants & grease.

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X-Gluc, is a chromogenic substrate used in a variety of applications for the detection of the X-glucuronidase enzyme. Upon reduction, X-Gluc produces a localized colour, making it useful in identifying GUS gene presence in most cell types and for the detection of the GUS gene fusion marker in plants.

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ABT-737 is a potent small-molecule inhibitor of antiapoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w with markedly higher affinity than previously reported compounds. ABT-737 induces apoptosis in MM cells, including those resistant to conventional therapy.

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AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.

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ATL1102 is an antisense drug that ATL is developing for the treatment of multiple sclerosis, or MS. ATL1102 inhibits CD49d, a subunit of Very Late Antigen-4, or VLA-4. Studies in animal models have demonstrated that inhibiting VLA-4 positively affects a number of inflammatory diseases, including MS. We licensed ATL1102 to ATL in December 2001 and in February 2008, ATL licensed ATL1102 to Teva.

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ATL1103 is an antisense drug that targets the growth hormone receptor, or GHr, a receptor that, when inhibited, reduces the level of circulating insulin-like growth factor-1, or IGF-1, produced in the liver.

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AZD5438 is a potent inhibitor of cyclin-dependent kinase. AZD5438 showed significant antiproliferative activity in human tumor cell lines causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH-terminal domain and blocking cell cycling at G(2)-M, S, and G(1) phases.

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Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production.

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