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Adjudin

Adjudin is a drug which is under development as a potential non-hormonal male contraceptive drug, which acts by blocking the production of sperm in the testes, but without affecting testosterone production.

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Adrafinil

Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time.

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Advantose 100

Advantose 100 is a spray-dried maltose powder that provides excellent flow, solubility, and tableting properties for oral dosage formulations.Advantose 100 has very low hygroscopicity, which makes it suitable for moisture sensitive actives. It also has good dilution potential and can be used with low bulk density materials. It does not show sensitivity to lubricant levels or mixing times and produces highly stable tablets.

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Advantose FS 95

Advantose FS 95 spray-dried fructose is coprocessed with a small quantity of starch, which results in a highly compressible excipient for pharmaceutical, nutraceutical, and chewable vitamin applications.Advantose FS 95 is composed of fructose, an extremely sweet compound, it can be used to mask undesirable flavors of components that may be in a tablet formulation. In addition to providing superior sweetness, products made with Advantose FS 95 will have a label that includes a natural occurring fruit sugar (fructose), which is desirable.

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Afatinib

Afatinib is a candidate drug against non-small cell lung carcinoma.

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Afimoxifene

Afimoxifene is a selective estrogen receptor modulator whose active ingredient is 4-hydroxytamoxifen which is identical to the active metabolite of tamoxifen. It is a transdermal gel formulation. It has completed a phase II clinical trial for the treatment of cyclical mastalgia.

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Agomelatine

Agomelatine is an antidepressant. It is marketed for the treatment of major depressive disorder and has been reported to have a reduced level of sexual side effects as well as discontinuation effects compared to some other antidepressants. Agomelatine may also have positive effects on sleep. Agomelatine resynchronises circadian rhythms in animal models of delayed sleep phase syndrome and other circadian rhythm disruptions. It increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin. Agomelatine has shown an antidepressant-like effect in animal models of depression as well as in models with circadian rhythm desynchronisation and in models related to stress and anxiety. In humans, agomelatine has positive phase shifting properties.

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Aigialomycin D

Aigialomycin d and a series of its analogues inhibit protein kinases related to cancer pathways.

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Ailamode

Ailamode is a novel oral antirheumatic agent for the treatment of rheumatoid arthritis.

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