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Guaiacol is a naturally occurring organic compound. Although it is biosynthesized by a variety of organisms, this colorless aromatic oil is usually derived from guaiacum or wood creosote. It is present in wood smoke, resulting from the pyrolysis of lignin. Guaiacol is a precursor to various flavorants such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as a dye in chemical reactions as oxygen will turn guaiacol from colorless to brown.

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Honokiol is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris that has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, anti-depressant, anti-emetic, and anti-bacterial. While early research on the effective compounds in traditional remedies have simply used whole magnolia bark extracts, known as houpu magnolia, recent work has identified honokiol and its structural isomer magnolol as the active compounds in magnolia bark. In the late 1990s, honokiol saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.

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ISIS-CRP is an antisense drug that targets CRP, a protein produced in the liver. CRP levels increase dramatically during inflammatory disorders, and scientists have linked excessive amounts of CRP to coronary artery disease. Furthermore, a growing body of evidence from clinical trials implicates CRP in cardiovascular disease progression.

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ISIS-FXI is an antisense drug we designed to treat clotting disorders. It targets Factor XI, a clotting factor produced in the liver that is an important component of the coagulation pathway.

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ISIS-PKK is an antisense drug designed to prevent hereditary angioedema, or HAE, attacks. It inhibits the production of prekallikren, or PKK, a protein produced in the liver that plays an important role in the activation of inflammatory mediators associated with acute attacks of HAE.

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ISIS-SMN is an antisense drug we designed to treat spinal muscular atrophy, or SMA, a severe motor-neuron disease that is the leading genetic cause of infant mortality.

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ISIS-TTR is an antisense drug we designed to treat transthyretin amyloidosis, or TTR amyloidosis, a severe and rare genetic disease in which the patient inherits a mutant gene that produces a misfolded form of TTR, which progressively accumulates in tissues.

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Ibogaine is a naturally occurring psychoactive substance found in a number of plants, principally in a member of the Apocynaceae family known as iboga. Some countries have banned this substance that has hallucinogen effects but in other countries it is being used to treat addiction to opiates, methamphetamine and other drugs.


Imatinib is a drug used to treat certain types of cancer.It is used in treating chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies.Side effects include nausea, vomiting, diarrhea, loss of appetite, dry skin, hair loss, swelling (especially in the legs or around the eyes) and muscle cramps.

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Ioversol is an organoiodine compound that used as a contrast medium. It features both high iodine content, as well as several hydrophilic groups. It is used in angiography and urography and for contrast enhancement in computed tomography.

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