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Anthranilic Acid

Anthranilic Acid is used as chemical intermediate for preparation of dyes & pigments . Anthranilic Acid & its esters used in perfumes & fungicides, & in saccharin, cadmium salt- an ascaricide in swine, mold inhibitor in soya sauce.

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Anthraquinone

Anthraquinone is an aromatic organic compound. This compound is an important member of the quinone family. It is a building block of many dyes and is industrially used in bleaching pulp for papermaking. A large industrial application of anthraquinones is for the production of hydrogen peroxide. Derivatives of 9,10-anthraquinone include many important drugs.

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Antimony

Antimony is a toxic chemical element. It is found in nature mainly as the sulfide mineral stibnite. Although the use of antimony is limited by its toxicity, its compounds have been of fundamental value in chemistry. Antimony compounds are prominent fire retardants found in many commercial and domestic products. Certain alloys are valuable for use in solders and ball bearings. An emerging application is the use of antimony in microelectronics. Few biological or medical applications exist for antimony. Treatments principally containing antimony are known as antimonials and are used as emetics. Antimony compounds are used as antiprotozoan drugs.

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Antipyrine

Antipyrine is an analgesic and antipyretic. It was first synthesized by Ludwig Knorr in 1883. It is formed by reducing diortho- dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 °C.

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Apaziquone

Apaziquone is an indolequinone that is a bioreductive prodrug and a chemical analog of the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptotic cell death. This activity is preferentially expressed in neoplastic cells. It has been applied in clinical studies for the treatment of superficial bladder cancer.

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Apixaban

English name

Chinese name

Quality standard

Certification

CAS NO

Therapeutic area

 

Apixaban

阿哌沙班

In-house

Non-GMP DMF is preparing

503612-47-3

Orthopaedics

 

 

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Apocynin

Apocynin is a natural organic compound structurally related to vanillin. It has been isolated from a variety of plant sources and is being studied for its variety of pharmacological properties. It is used as an inhibitor of NADPH oxidase.

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Apomorphine

Apomorphine is a non-selective dopamine agonist which activates both D1-like and D2-like receptors, with some preference for the latter subtypes. It was used with some notable success as a treatment for alcohol and morphine addiction. It is used in the treatment of Parkinson's disease. It is a potent emetic and should not be administered without an antiemetic such as domperidone. The emetic properties of apomorphine are exploited in veterinary medicine to induce therapeutic emesis in canines that have recently ingested toxic or foreign substances. It has been reported to be an inhibitor of Beta amyloid fibril formation, and may thus have potential as a therapeutic for Alzheimer's disease. It was also successfully used as an unofficial treatment of heroin addiction. Apomorphine hydrochloride was a therapy used in the treatment of erectile dysfunction.

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Apraclonidine

Apraclonidine is a sympathomimetic used in glaucoma therapy. It is an α2-adrenergic agonist. It is indicated for the short-term adjunctive treatment of patients on maximally tolerated medical therapy who require additional reduction. Patients on maximally tolerated medical therapy who are treated with apraclonidine to delay surgery should have frequent followup examinations and treatment should be discontinued if the intraocular pressure rises significantly.

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Apremilast

Apremilast is a novel, orally available PDE4 inhibitor that inhibits spontaneous TNFα production from human rheumatoid synovial membrane cultures, ex-vivo, with similar efficacy to rolipram.

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