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The two chemists, William Crookes and Claude-Auguste Lamy, discovered thallium independently in 1861 by the newly developed method of flame spectroscopy. Both discovered the new element in residues of sulfuric acid production. Approximately 60–70% of thallium production is used in the electronics industry, and the rest is used in the pharmaceutical industry and in glass manufacturing. It is also used in infrared detectors. It is highly toxic and was used in rat poisons and insecticides. Its use has been cut back or eliminated in many countries because of its nonselective toxicity.

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Tiapride is a benzamide derivative with dopamine antagonist actions similar to sulpiride. It has been used as an antipsychotic and in the treatment of various movement disorders and alcoholism.

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Tramadol is a narcotic analgesic proposed for severe pain. It may be habituating.Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists.

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Udenafil is a drug used in urology to treat erectile dysfunction. It belongs to a class of drugs called PDE5 inhibitor, which many other erectile dysfunction drugs such as sildenafil, tadalafil, and vardenafil also belong to. It was developed by Dong-A Pharmaceutical. It is not approved for use in the United States by the U.S. Food and Drug Administration.


Ursodiol is an epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. Ursodiol reduces elevated liver enzyme levels by facilitating bile flow through the liver and protecting liver cells. The most likely manifestation of severe overdose with Ursodiol would probably be diarrhea, which should be treated symptomatically.

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Vanillin is a phenolic aldehyde, which is an organic compound. Vanillin functional groups include aldehyde, hydroxyl, and ether. It is the primary component of the extract of the vanilla bean.Vanillin was first isolated as a relatively pure substance in 1858 by Nicolas-Theodore Gobley.Vanillin is most prominent as the principal flavor and aroma compound in vanilla.Vanillin is also used in the fragrance industry, in perfumes, and to mask unpleasant odors or tastes in medicines, livestock fodder, and cleaning products.It is also used in the flavor industry, as a very important key note for many different flavors, especially creamy profiles like cream soda.Vanillin has been used as a chemical intermediate in the production of pharmaceuticals and other fine chemicals.Vanillin can trigger allergic reactions.

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Vorozole is an imidazole based competitive inhibitor of the aromatase enzyme. It underwent clinical testing for evaluation for use as an antineoplastic agent; however it was withdrawn from testing when no difference was detected in the duration of median survival as compared to the progestational agent megestrol acetate and research instead focused on the other third generation aromatase inhibitors anastrozole, letrozole and exemestane.


Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

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XMT-1001 is a novel cytotoxic drug conjugate from the established "tecan" drug class with proven broad activity across solid tumors. XMT-1001 is a conjugate of a novel camptothecin analog, the Fleximer® polymer backbone and a customized linker, and was designed to produce a prolonged exposure to the tumor and to improve the safety and efficacy of the active drug payload. XMT-1001 works by inhibiting the topoisomerase 1 enzyme, thereby causing highly proliferating tumor cells to die.

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