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Alinidine is a negative chronotrope that was developed in the 70's and 80's. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold. The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential.


Aliskiren is the first in a class of drugs called direct renin inhibitor. Its current licensed indication is primary hypertension.

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Alosetron is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome in women only.

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Amibegron is a drug which acts as a selective agonist for the β3 adrenergic receptor. It is the first orally active β3 agonist developed that is capable of entering the central nervous system, and has antidepressant and anxiolytic effects.

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Amiloride is a new, well tolerated oral natriuretic and mild diuretic agent, has been evaluated alone and in combination with other diuretics. Its remarkable ability to promote retention rather than loss of potassium makes it a useful adjunct in the management of even the most severe edematous states. It also retards the alkalosis produced by certain of the stronger diuretics by blocking hydrogen secretion and promoting bicarbonate loss.Amiloride is used to treat or prevent hypokalemia.

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Amoxapine is a tetracyclic antidepressant of the dibenzoxazepine family, though it is often classified as a secondary amine tricyclic antidepressant. It is the N-demethylated metabolite of Loxapine. It is used in the treatment of depression, anxiety disorders, panic disorder, and bipolar disorder. It also has properties similar to those of atypical antipsychotic, and may be used in the treatment of schizophrenic psychosis off-label.

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Amrubicin is an anthracycline used in the treatment of lung cancer. It has also been studied for the treatment of bladder carcinoma and gastric cancer.

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Ancarolol is a beta blocker.


Annamycin is an anthracycline antibiotic being investigated for the treatment of cancer.


Arecoline is an alkaloid natural product found in the areca nut, the fruit of the areca palm. Owing to its muscarinic and nicotinic agonist properties, arecoline has shown improvement in the learning ability of healthy volunteers. Since one of the hallmarks of Alzheimer's disease is a cognitive decline, arecoline was suggested as a treatment to slow down this process and arecoline administered intravenously did indeed show modest verbal and spatial memory improvement in Alzheimer's patients, though due to arecoline's possible carcinogenic properties, it is not the first drug of choice for this degenerative disease. It has also been used medicinally as an antihelmintic.

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