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Aciclovir is a guanosine analogue antiviral drug. One of the most commonly used antiviral drugs, it is primarily used for the treatment of herpes simplex virus infections, as well as in the treatment of varicella zoster and herpes zoster.

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Acitretin is a second generation retinoid. It is a metabolite of etretinate.It is taken orally, and is typically used for psoriasis.Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.

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Adapalene is a third-generation topical retinoid.It is primarily used in the treatment of mild-moderate acne and is also used to treat keratosis pilaris as well as other skin conditions,topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.Adapalene in small concentrations is a moderator of cellular differentiation, keratinization, and inflammatory processes. It has both exfoliating and anti-inflammatory effects.

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Adrafinil is a mild central nervous system stimulant drug used to relieve excessive sleepiness and inattention in elderly patients. It is also used off-label by individuals wishing to avoid fatigue, such as night workers or others who need to stay awake and alert for long periods of time.

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Akuammine, an indole alkaloid, is the most abundant active alkaloid found in the seeds from the tree Picralima nitida, commonly known as Akuamma. The seeds are mainly used for the treatment of malaria and diarrhoea, and as a painkiller. Akuammine is structurally related to both yohimbine and mitragynine, both of which are alkaloid plant products with uses in medicine.


Alazocine was the first drug discovered to act as a σ1 receptor agonist. It has no significant affinity for the σ2 receptor. It also acts as a κ-opioid receptor agonist, and to a much lesser extent, as an NMDA receptor antagonist.


Albuterol is a bronchodilator that relaxes muscles in the airways and increases air flow to the lungs. It is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease.Albuterol inhalation is used to treat or prevent bronchospasm in people with reversible obstructive airway disease. Albuterol is also used to prevent exercise-induced bronchospasm.Albuterol controls symptoms of asthma and other lung diseases but does not cure them.

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Alfuzosin is an α1 receptor antagonist used to treat benign prostatic hyperplasia. It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.

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Alinidine is a negative chronotrope that was developed in the 70's and 80's. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold. The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential.


Aliskiren is the first in a class of drugs called direct renin inhibitor. Its current licensed indication is primary hypertension.

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