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Alosetron is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome in women only.

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Amibegron is a drug which acts as a selective agonist for the β3 adrenergic receptor. It is the first orally active β3 agonist developed that is capable of entering the central nervous system, and has antidepressant and anxiolytic effects.

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Amiloride is a new, well tolerated oral natriuretic and mild diuretic agent, has been evaluated alone and in combination with other diuretics. Its remarkable ability to promote retention rather than loss of potassium makes it a useful adjunct in the management of even the most severe edematous states. It also retards the alkalosis produced by certain of the stronger diuretics by blocking hydrogen secretion and promoting bicarbonate loss.Amiloride is used to treat or prevent hypokalemia.

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Amoxapine is a tetracyclic antidepressant of the dibenzoxazepine family, though it is often classified as a secondary amine tricyclic antidepressant. It is the N-demethylated metabolite of Loxapine. It is used in the treatment of depression, anxiety disorders, panic disorder, and bipolar disorder. It also has properties similar to those of atypical antipsychotic, and may be used in the treatment of schizophrenic psychosis off-label.

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Amrubicin is an anthracycline used in the treatment of lung cancer. It has also been studied for the treatment of bladder carcinoma and gastric cancer.

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Ancarolol is a beta blocker.


Annamycin is an anthracycline antibiotic being investigated for the treatment of cancer.


Arecoline is an alkaloid natural product found in the areca nut, the fruit of the areca palm. Owing to its muscarinic and nicotinic agonist properties, arecoline has shown improvement in the learning ability of healthy volunteers. Since one of the hallmarks of Alzheimer's disease is a cognitive decline, arecoline was suggested as a treatment to slow down this process and arecoline administered intravenously did indeed show modest verbal and spatial memory improvement in Alzheimer's patients, though due to arecoline's possible carcinogenic properties, it is not the first drug of choice for this degenerative disease. It has also been used medicinally as an antihelmintic.

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Ascomycin is an ethyl analog of tacrolimus with strong immunosuppressant properties. It can be used to treat autoimmune diseases and skin diseases, and can help prevent rejection after an organ transplant. It acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 and Th2 cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically.

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Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder by Schering-Plough. Preliminary data indicate that it has minimal anticholinergic and cardiovascular side effects, as well as minimal weight gain.

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