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Annamycin

Annamycin is an anthracycline antibiotic being investigated for the treatment of cancer.

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Arecoline

Arecoline is an alkaloid natural product found in the areca nut, the fruit of the areca palm. Owing to its muscarinic and nicotinic agonist properties, arecoline has shown improvement in the learning ability of healthy volunteers. Since one of the hallmarks of Alzheimer's disease is a cognitive decline, arecoline was suggested as a treatment to slow down this process and arecoline administered intravenously did indeed show modest verbal and spatial memory improvement in Alzheimer's patients, though due to arecoline's possible carcinogenic properties, it is not the first drug of choice for this degenerative disease. It has also been used medicinally as an antihelmintic.

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Ascomycin

Ascomycin is an ethyl analog of tacrolimus with strong immunosuppressant properties. It can be used to treat autoimmune diseases and skin diseases, and can help prevent rejection after an organ transplant. It acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 and Th2 cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically.

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Asenapine

Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder by Schering-Plough. Preliminary data indicate that it has minimal anticholinergic and cardiovascular side effects, as well as minimal weight gain.

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Aspartame

Aspartame is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. It is a white, odourless powder, approximately 200 times sweeter than sugar, manufactured by combining phenylalanine and aspartic acid. Its main impurity is diketopiperazine that has no sweetening properties. It is not only used in food but also in pharmaceutical also.

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Avosentan

Avosentan is an endothelin-A antagonist, decreases the urinary albumin excretion rate (UAER) in patients with diabetes and macroalbuminuria when added to standard therapy with an angiotensin-converting enzyme (ACE) inhibitor and/or angiotensin receptor blocker (ARB).

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Azaserine

Azaserine is a carcinogen primarily used for researching pancreatic cancer in animal models. It is a glutamine analogue that irreversibly inhibits glutamine utilizing enzymes such as Gln: Phosphoribosyl Amidotransferase, which is involved in the biosynthesis of Inosine monophosphate .

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Azasetron

Azasetron is an antiemetic which acts as a 5-HT3 receptor antagonist.

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Azatadine

Azatadine is an antihistamine. Azatadine blocks the effects of the naturally occurring chemical histamine in your body. Azatadine is used to treat sneezing, runny nose, itching, watery eyes, hives, rashes, itching and other symptoms of allergies and the common cold.

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Azimilide

Azimilide is a class ΙΙΙ antiarrhythmic drug. The agents from this heterogeneous group have an effect on the repolarization, they prolong the duration of the action potential and the refractory period. Also they slow down the spontaneous discharge frequency of automatic pacemakers by depressing the slope of diastolic depolarization. They shift the threshold towards zero or hyperpolarize the membrane potential. Although each agent has its own properties and will have thus a different function.

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